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Microglial activation and white matter abnormality in autism : MRI and PET study

Research Project

Project/Area Number 21791124
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

TAKEBAYASHI Kiyokazu  Hamamatsu University School of Medicine, 子どものこころの発達研究センター, 特任助教 (50397428)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords自閉症 / 軸索 / ミクログリア / 脳画像
Research Abstract

Patients with autism had significantly higher [11C](R)-PK11195 BPs than control subjects in the ROIs ; brain stem, cerebellum, thalamus, frontal, temporal, and occipital lobe, compared to healthy comparison subjects. This results suggests that there are microglial activation in those brain areas in autism, which indicates that neuroinflammation underlies the pathology of autism.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Remarks (1 results)

  • [Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders.2011

    • Author(s)
      Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N.
    • Journal Title

      Arch Gen Psychiatry. 68(3)

      Pages: 306-313

    • Related Report
      2010 Final Research Report
  • [Journal Article] Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders.2011

    • Author(s)
      Suzuki K, Matsuzaki H, Iwata K, Kameno Y, Shimmura C, Kawai S, Yoshihara Y, Wakuda T, Takebayashi K, Takagai S, Matsumoto K, Tsuchiya KJ, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Mori N
    • Journal Title

      PLoS One. 6(5)(Epub 2011 May 27)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders.2011

    • Author(s)
      Suzuki, et al.
    • Journal Title

      Arch Gen Psychiatry

      Volume: 68 Pages: 306-313

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] metabolite alterations in the hippocampus of high-functioning adult subjects with autism2010

    • Author(s)
      鈴木勝昭
    • Journal Title

      Int J Neuropsychopharmacol VOL.13

      Pages: 529-534

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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