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VLDLR overexpression rat : evaluation as an animal model of autism

Research Project

Project/Area Number 21791126
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

IWATA Keiko  Hamamatsu University School of Medicine, 子どものこころの発達研究センター, 助教 (30415088)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords児童 / 思春期精神医学 / 自閉症 / ラット / VLDLR / Reelin
Research Abstract

It has been reported that level of VLDLR mRNA was increased in post mortem studies of autistic brain. In this study, we generated transgenic (Tg) rats overexpressing VLDLR and examined its histological and behavioral features. Results indicated that the spontaneous locomotor activity in Tg rats was significantly increased without detectable changes in histology. Additionally, Tg rats tended to show performance deficits in radial maze, suggesting that spatial working memory was slightly impaired. These results suggest that VLDLR level might be involved in locomotor activity and memory function. Patients with neurodevelopmental or psychiatric disorders do not show striking neuroanatomical aberration. Therefore, it is significant for the clinical aspect that these behavioral phenotypes were detected without neuroanatomical abnormality in VLDLR Tg rats.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 6 results) Presentation (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Animal models of autism : an epigenetic and environmental viewpoint.2010

    • Author(s)
      Iwata K, Matsuzaki H, Takei N, Manabe T, Mori N.
    • Journal Title

      Journal of Central Nervous System Disease 2

      Pages: 37-44

    • Related Report
      2010 Final Research Report
  • [Journal Article] Reduced expression of apolipoprotein E receptor type 2 in peripheral blood lymphocytes from patients with major depressive disorder.2010

    • Author(s)
      Suzuki K, Iwata Y, Matsuzaki H, Anitha A, Suda S, Iwata K, Shinmura C, Kameno Y, Tsuchiya KJ, Nakamura K, Takei N, Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 34

      Pages: 1007-1010

    • Related Report
      2010 Final Research Report
  • [Journal Article] Novel Events in Mitchondria : Increase of Poly(ADP-ribosyl)ation in Human Promyelocytic Leukemia HL-60 Cell Line during Differentiation by Nicotinamide.2010

    • Author(s)
      Iwata, K., Ogata, S., Taguchi, H.
    • Journal Title

      Process Biochemistry 45

      Pages: 54-59

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia : the Japanese population and meta-analysis.2010

    • Author(s)
      Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, Nakamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. B 153

      Pages: 1221-1227

    • Related Report
      2010 Final Research Report
  • [Journal Article] Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats : reversal by fluoxetine.2010

    • Author(s)
      Suzuki K, Okada K, Wakuda T, Shinmura C, Kameno Y, Iwata K, Takahashi T, Suda S, Matsuzaki H, Iwata Y, Hashimoto K, Mori N.
    • Journal Title

      PLoS One 17;5(2)

    • NAID

      120005314217

    • Related Report
      2010 Final Research Report
  • [Journal Article] Decreased serum levels of adiponectin in subjects with autism.2010

    • Author(s)
      Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M, Shinmura C, Iwata Y, Suda S, Tsuchiya KJ, Matsumoto K, Sugihara G, Iwata K, Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 34

      Pages: 455-458

    • Related Report
      2010 Final Research Report
  • [Journal Article] Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism.2010

    • Author(s)
      Kajizuka M, Miyachi T, Matsuzaki H, Iwata K, Shinmura C, Suzuki K, Suda S, Tsuchiya KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 34

      Pages: 154-158

    • Related Report
      2010 Final Research Report
  • [Journal Article] Animal models of autism : an epigenetic and environmental viewpoint.2010

    • Author(s)
      Iwata K, Matsuzaki H, Takei N, Manabe T, Mori N.
    • Journal Title

      Journal of Central Nervous System Disease

      Volume: 2 Pages: 37-44

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia : the Japanese population and meta-analysis.2010

    • Author(s)
      Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, Nakamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet.

      Volume: 153B Pages: 1221-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of apolipoprotein E receptor type 2 in peripheral blood lymphocytes from patients with major depressivedisorder.2010

    • Author(s)
      Suzuki K, Iwata Y, Matsuzaki H, Anitha A, Suda S, Iwata K, Shinmura C, Kameno Y, Tsuchiya KJ, Nakamura K, Takei N, Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry.

      Volume: 34 Pages: 1007-10

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats : reversal by fluoxetine.2010

    • Author(s)
      Suzuki K, Okada K, Wakuda T, Shinmura C, Kameno Y, Iwata K, Takahashi T, Suda S, Matsuzaki H, Iwata Y, Hashimoto K, Mori N.
    • Journal Title

      PLoS One 17

    • NAID

      120005314217

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased serum levels of adiponectin in subjects with autism2010

    • Author(s)
      Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M, Shinmura C, Iwata Y, Suda S, Tsuchiya KJ, Matsumoto K, Sugihara G, Iwata K, Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 34

      Pages: 455-458

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism.2010

    • Author(s)
      Kajizuka M, Miyachi T, Matsuzaki H, Iwata K, Shinmura C, Suzuki K, Suda S, Tsuchiya KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 34

      Pages: 154-158

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] VLDLR overexpression rat : evaluation as an animal model of autism.2010

    • Author(s)
      Iwata, K., Matsuzaki, H., Izumo, N., Ichitani, Y., Mori, N.
    • Organizer
      Society for neuroscience 2010
    • Place of Presentation
      San Diego, California
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 高機能自閉症の発症危険度を判定する方法およびマーカー2010

    • Inventor(s)
      森則夫、中村和彦、鈴木勝昭、土屋賢治、岩田圭子、松崎秀夫
    • Industrial Property Rights Holder
      国立大学法人 浜松医科大学
    • Filing Date
      2010-10-14
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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