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Inhibition of endocytosis by sertraline leads to causal factors of depression

Research Project

Project/Area Number 21791152
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionSt.Marianna University School of Medicine

Principal Investigator

TAKAHASHI Kiyofumi  St.Marianna University School of Medicine, 医学部, 研究技術員 (70398965)

Co-Investigator(Renkei-kenkyūsha) MIYOSHI Hiroshi  聖マリアンナ医科大学, 医学部, 講師 (80322519)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脳・神経 / 向精神薬 / エンドサイトーシス / Dynamin
Research Abstract

Sertraline, an antidepressant belonging to selective serotonin reuptake inhibitors (SSRI), inhibits GTPase activity of dynamin which plays an important role in membrane fission on endocytosis. It was revealed that sertraline is a mixed-type inhibitor of the GTPase activity with respect to both guanosine 5'-triphosphate (GTP) and 3-sn-phosphatidyl-L-serine (PS)-liposome, and does not inhibit dynamin self-assembly for oligomerization.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Suppression of dynamin GTPase activity by sertraline leads to inhibition of dynamin-dependent endocytosis.2010

    • Author(s)
      Kiyofumi Takahashi, Hiroshi Miyoshi, Masahiro Otomo, Kenichi Osada, Noboru Yamaguchi, Hideki Nakashima.
    • Journal Title

      Biochemistry and Biophysical Research Communications 391(1)

      Pages: 382-387

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of dynamin GTPase activity by sertraline leads to inhibition of dynamin-dependent endocytosis.2010

    • Author(s)
      Takahashi, K., et al.
    • Journal Title

      Biochemical and Biophysical Research Communications 391

      Pages: 382-387

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Suppression of dynamin GTPase activity by sertraline inhibits dynamin-dependent endocytosis2010

    • Author(s)
      Takahashi, K.
    • Organizer
      Francis Crick Symposium on Neuroscience
    • Place of Presentation
      Cold Spring Harbor Asia, Suzhou, China
    • Year and Date
      2010-04-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Suppression of dynamin GTPase activity by sertraline inhibits dynamin-dependent endocytosis.2010

    • Author(s)
      Kiyofumi Takahashi.
    • Organizer
      Francis Crick Symposium on Neuroscience held at Cold Spring Harbor Conferences Asia
    • Place of Presentation
      Suzhou, China
    • Related Report
      2010 Final Research Report
  • [Presentation] SertralineはdynaminのGTPase活性を抑制しdynamin依存的なendocytosisを阻害する2009

    • Author(s)
      高橋清文
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sertraline inhibits endocytosis via suppression for dynamin GTPase2009

    • Author(s)
      Kiyofumi Takahashi
    • Organizer
      第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同年会 および第1回アジア神経精神薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] sertralineはdynaminのGTPase活性を抑制しdynamin依存的なendocytosisを阻害する2009

    • Author(s)
      高橋清文
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Related Report
      2010 Final Research Report
  • [Presentation] Sertraline inhibits endocytosis via suppression for dynamin GTPase.2009

    • Author(s)
      高橋清文
    • Organizer
      第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同年会、第1回アジア神経精神薬理学会
    • Place of Presentation
      京都市
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://mariannapsycho.web.fc2.com/kenkyuu.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://mariannapsycho.web.fc2.com/kenkyuu.html

    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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