Research of aiming at the establishment of comprehensive diagnosis and therapy of metastatic bone cancer using novel radiopharmaceuticals
Project/Area Number |
21791174
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Radiation science
|
Research Institution | Kanazawa University |
Principal Investigator |
OGAWA Kazuma Kanazawa University, 薬学系, 准教授 (30347471)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | イメージング / PET / 転移性骨腫瘍 |
Research Abstract |
DOTA-conjugated bisphosphonate was synthesized using bisphosphonate as a carrier to bone. ^<67>Ga-DOTA-conjugated bisphosphonate was prepared with a radiochemical purity of over 95% without purification. In biodistribution experiments, ^<67>Ga-DOTA-conjugated bisphosphonate accumulated in bone rapidly but were hardly observed in tissues other than bone. These results indicate that ^<67>Ga-DOTA-conjugated bisphosphonate has ideal biodistribution characteristics as bone-imaging agents.
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Report
(3 results)
Research Products
(9 results)