| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
The rupture of atherosclerotic vulnerable plaques and the subsequent formation of thrombi are the main factors responsible for myocardial and cerebral infarctions. Macrophage infiltration is characteristics for atherosclerotic vulnerable plaques. Macrophages recognize phosphatidylserine(PS) that is exposed on the cell surface of the apoptotic cells to phagocytize these cells. In this study, we prepared PS liposomes for detection of vulnerable plaques. As a result, the atherosclerotic region was detected by this imaging probe.
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