Is ^1H-MR-spectroscopy useful for the estimation of thyroid nodule detected by FDG-PET/CT?
| Project/Area Number |
21791207
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
OKUYAMA CHIO Kyoto Prefectural University of Medicine, 医学研究科, 講師 (40347464)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 甲状腺結節 / 甲状腺癌 / F-18-fluoro-deoxy-glucose positron emission tomography / 1H-MRスペクトロスコピー / 画像診断 / FDG-PET / MRS / 良悪性 / I-131 / 甲状腺癌転移 |
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| Research Abstract |
FDG-PET detects frequently thyroid incidentalomas. We retrospectively obtained histopathological verification for the incidentally found thyroid nodule by FDG-PET or PET/CT performed from April 2009 until May 2006 testing in 5,027 patients. One-hundred and 25 thyroid nodules were noted, and histological verification been made 45 of them (27 malignant lesion, and 18 benign lesions by biopsy or resection). The Standardized Uptake value (SUVmax in the nodules) (mean±SD) of malignant lesion was not significantly differed from the benign lesions; malignant3.8±5.4, benign 2.3±3.7).
Next step, we planned to perform 1H MR-spectroscopy for the cases with FDG-PET positive thyroid nodules in April 2010 to March 2011. FDG-PET/CT was performed in 1535 cases, and 18 patients had incidental FDG-positive thyroid nodules more than 1cm.However, 16 of these cases were unexpectedly excluded from this research, because the consent was not obtained, or the treatment of the underlying disease was prioritized. The remaining two cases, the diagnosis of adenomatous goiter in the neck ultrasonography, and biopsy was not performed extraction.
Initially, in this study, FDG for thyroid nodules positive, 1H-MRS peak detection and Colin thyroid nodules by, was intended for it to evaluate the malignant status and it is difficult to perform, we changed the plan. The FDG or I-131 positive lesions after total thyroidectomy in patients with thyroid carcinoma were the next target for the 1H-MRS study.
FDG or I-131-positive cervical, mediastinal lesions could be confirmed by MRI. The detection of a meaningful spectrum in the large deflection of the baseline of MRS. For qualitative diagnosis for thyroid gland surgery nodule found in the neck to use 1H-MRS is currently considered to be fraught with challenges.
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Report
(3 results)
Research Products
(23 results)
