Development of novel kind of p53 inhibitorsthat target the zincbinding site of p53
| Project/Area Number |
21791218
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Tokyo University of Science |
|---|
Principal Investigator |
MORITA Akinori Tokyo University of Science, 理工学部, 助教 (90334234)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | p53阻害剤 / 放射線防護剤 / 亜鉛キレート化剤 / DNA損傷 / アポトーシス / 金属錯体 |
|---|
| Research Abstract |
We evaluated some zinc chelators for inhibition of p53-dependent apoptosis. As a result, two out of five zinc chelators suppressed the apoptosis. Our findings indicate that using zinc chelation would be a new approach to inhibition of the apoptotic pathways.
|
Report
(3 results)
Research Products
(40 results)
-
-
-
-
-
-
[Journal Article] Sodium orthovanadate inhibits p53-mediated apoptosis.2010
Author(s)
A.Morita, S.Yamamoto, B.Wang, K.Tanaka, N.Suzuki, S.Aoki, A.Ito, T.Nanao, S.Ohya, M.Yoshino, J.Zhu, A.Enomoto, Y.Matsumoto, O.Funatsu, Y.Hosoi, M.Ikekita.
-
Journal Title
Caneer Res. 70
Pages: 257-265
Related Report
Peer Reviewed
-
[Journal Article] Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.2010
Author(s)
N.Sasano, A.Enomoto, Y.Hosoi, Y.Katsumura, Y.Matsumoto, A.Morita, K.Shiraishi, K.Miyagawa, H.Igaki, K.Nakagawa.
-
Journal Title
Cancer lett. 293
Pages: 53-57
Related Report
Peer Reviewed
-
[Journal Article] Design and synthesis of a fluorescent probe for Zn2+, 5,7-bis(N,N-dimethylaminosulfonyl)-8-hydroxyquinoline-pendant 1,4,7,10-tetraazacyclododecane and Zn2+-dependent hydrolytic and Zn2+-independent photochemical reactivation of its benzenesulfonyl-caged derivative.2010
Author(s)
R.Ohshima, M. Kitamura, A. Morita, M.Shiro, Y.Yamada, M.Ikekita, E.Kimura, S.Aoki.
-
Journal Title
Inorganie Chem. 49
Pages: 888-899
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
