The structural change in the brain of the people with an At Risk Mental State(ARMS) for psychosis : the optimization of MR imaging for analysis
| Project/Area Number |
21791219
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Juntendo University |
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Principal Investigator |
HORI Masaaki 順天堂大学, 医学部, 准教授 (40334867)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUNO Masafumi 東邦大学, 医学部, 教授 (80245589)
ISHIGAME Keiichi 山梨大学, 医学部, 助教 (30360358)
AOKI Shigeki 順天堂大学, 医学部, 教授 (80222470)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | MRI / 前期状態 / 拡散テンソル / 画像統計解析 / 統合失調症 |
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| Research Abstract |
We tried to analyze the structural change in the brain of the people with an At Risk Mental State(ARMS) for psychosis by using Voxel based morphometry(VBM) and diffusion tensor imaging(DTI) at 1.5 T MRI. At the first MR examination, partial brain atrophy such as entorhinal cortex and DTI abnormalities in the cingulum and frontal white matter have been observed in the objects with an ARMS who did not develop psychosis later, compared with normal controls. The results suggested vulnerability to psychosis.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article]2011
Author(s)
青木茂樹, 堀正明他4名
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Journal Title
拡散MRIの臨床応用
Volume: 51巻
Pages: 955-955
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