Structural and functional synergy for quantitative PET images

• Project/Area Number: 21791230
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: SHIDAHARA Miho National Institute of Radiological Sciences, 大学院・医学系研究科, 講師 (20443070)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 核医学 / 動態解析 / ウェーブレット / PET/MRI / 医用画像処理 / シミュレーション / PET / MRI

Research Abstract

Using a wavelet-based resolution recovery method named SFS-RR (structural and functional synergy for resolution recovery), we have demonstrated that the structural image effectively recovers the true signal in cortical areas (Shidahara et al., 2009). In the current work, we evaluate the performance of the recovery strategy in the case of the quantification of dopaminegic function in striatal regions. The proposed methodology proved effective in the resolution recovery of small structures of brain [^<11>C]raclopride PET images and the improvement is consistent across the anatomical variability of a simulated population.

Research Products

• [Journal Article] 陽電子断層撮影装置(PET)を用いた脳神経受容体機能の定量解析 (2011)
  • Author(s): 志田原美保、田村元
  • Journal Title: 東北大医学部保健学科紀要 Volume: 20 Pages: 1-16
  • NAID: 120002773806
  • Peer Reviewed
• [Journal Article] Positron emission tomography inter-scanner differences in dopamine D2 receptor binding measured with [11C]FLB457. (2010)
  • Author(s): Kodaka F, Ito H, Shidahara M, Takano H, Takahashi H, Arakawa R, Nakayama K, Suhara T
  • Journal Title: Ann Nucl Med. 24巻9号 Pages: 671-677
  • Peer Reviewed
• [Journal Article] Quantitative Analysis of Dopamine Transporters in Human Brain Using [11C]PE2I and Positron Emission Tomography : Evaluation of Reference Tissue Models. (2010)
  • Author(s): Seki C, Ito H, Ichimiya T, Arakawa R, Ikoma Y, Shidahara M, Maeda J, Takano A, Takahashi H, Kimura Y, Suzuki K, Kanno I, Suhara T
  • Journal Title: Ann Nucl Med. 24巻4号 Pages: 249-260
  • NAID: 10026509094
  • Peer Reviewed
• [Journal Article] Measurement Error analysis for the determination of dopamine D2 receptor occupancy using agonist radioligand [11C]MNPA. (2010)
  • Author(s): Shidahara M, Ito H, Otsuka T, Ikoma Y, Arakawa R, Kodaka F, Seki C, Takano H, Takahashi H, Turkheimer FE, Kimura Y, Kanno I, Suhara T.
  • Journal Title: J Cereb Blood Flow & Metab 30巻1号 Pages: 187-195
  • Peer Reviewed
• [Journal Article] A New Graphic Plot Analysis for Determination of Neuroreceptor Binding in Positron Emission Tomography Studies. (2010)
  • Author(s): Ito H, Yokoi T, Ikoma Y, Shidahara M, Seki C, Naganawa M, Takahashi H, Takano H, Kimura Y, Ichise M, Suhara T.
  • Journal Title: Neuroimage. 49巻1号 Pages: 578-586
  • Peer Reviewed
• [Journal Article] Positron emission tomography inter-scanner differences in dopamine D2 receptor binding measure with [11C]FLB457 (2010)
  • Author(s): Kodaka F, Ito H, Shidahara M, et al.
  • Journal Title: Ann Nucl Med Volume: 24 Pages: 671-677
  • Peer Reviewed
• [Journal Article] Quantitative Analysis of Dopamine Transporters in Human Brain Using [11C]PE2I and Positron Emission Tomography (2010)
  • Author(s): Seki C, Ito H, Ichimiya T, et al.
  • Journal Title: Ann Nucl Med Volume: 24 Pages: 249-260
  • Peer Reviewed
• [Journal Article] Error analysis for the determination of dopamine D_2 receptor occupancy using agonist radioliand [11C]MNPA (2010)
  • Author(s): Miho Shidahara, et al.
  • Journal Title: J Cereb Blood Flow & Metab 30(1) Pages: 187-195
  • Peer Reviewed
• [Journal Article] Improvement of likelihood estimation in Logan graphical analysis using Maximum A posteriori for Neuroreceptor PET imaging. (2009)
  • Author(s): Shidahara M, Seki C, Naganawa M, Sakata M, Ishikawa M, Ito H, Kanno I, Suhara T, Ishiwata K, Kimura Y.
  • Journal Title: Ann Nucl Med. 23巻2号 Pages: 163-171
  • NAID: 10025135723
  • Peer Reviewed
• [Journal Article] No regional difference in dopamine D2 receptor occupancy by the second-generation antipsychotic drug risperidone in humans : a positron emission tomography study. (2009)
  • Author(s): Ito H, Arakawa R, Takahashi H, Takano H, Okumura M, Otsuka T, Ikoma Y, Shidahara M, Suahra T.
  • Journal Title: Int J Neurophsychopharmacology. 12巻 Pages: 667-675
  • Peer Reviewed
• [Journal Article] Functional and structural synergy for resolution recovery and partial volume correction in brain PET. (2009)
  • Author(s): Shidahara M, Tsoumpas C, Hammers A, Boussion N, Visvikis D, Suhara T, Kanno I, Turkheimer FE.
  • Journal Title: Neuroimage. 44巻2号 Pages: 340-348
  • Peer Reviewed
• [Journal Article] Functional and structural synergy for resolution recovery and partial volume correction in brain PET (2009)
  • Author(s): Miho Shidahara, et al.
  • Journal Title: Neuroimage 44(2) Pages: 340-348
  • Peer Reviewed
• [Journal Article] Improvement of likelihood estimation in Logan graphical analysis using Maximum A posteriori for Neuroreceptor PET imaging (2009)
  • Author(s): Miho Shidahara, et al.
  • Journal Title: Ann Nucl Med 23(2) Pages: 163-171
  • NAID: 10025135723
  • Peer Reviewed
• [Presentation] [11C]MNPAを用いたドーパミンD2受容体占有率測定における誤差解析 (2010)
  • Author(s): 志田原美保、伊藤浩、大塚達以, ら, 他10名
  • Organizer: 第50回日本核医学会総会
  • Place of Presentation: 大宮
  • Year and Date: 2010-11-11
• [Presentation] Quantitative evaluation of 11C-PIB binding in amyloid precursor protein transgenic mouse brains (2010)
  • Author(s): Seki C, Higuchi M, Tokunaga M, Hattori S, Maruyama M, Shidahara M, Okauchi T, Nakao R, Maeda J, Kimura Y, Kanno I, Suhara T
  • Organizer: Functional Neuroreceptor Mapping of the Living Brain (NRM2010)
  • Place of Presentation: Grasgow, UK
  • Year and Date: 2010-07-23
• [Presentation] Correction Of [11C]Diprenorphine PET Data For The Partial-Volume Effect : Application to Quantification Of Opioid Receptor Binding Following Spontaneous Epileptic Seizures (2010)
  • Author(s): McGinnity CJ, Shidahara M, Keihaninejad S, Riano Barros DA, Gousias IS, Heckemann RA, Koepp MJ, Turkheimer FE, Hammers A
  • Organizer: Functional Neuroreceptor Mapping of the Living Brain (NRM2010)
  • Place of Presentation: Grasgow, UK
  • Year and Date: 2010-07-23
• [Presentation] Quantifiaction of opioid receptor availability following spontaneous epilepticseizures (2010)
  • Author(s): McGinnity CJ, Shidahara M, Keihaninejad S, Riano Barros DA, Gousias IS, Heckemann RA, Koepp MJ, Turkheimer FE, Hammers A
  • Organizer: 9th EUROPEAN CONGRESS ON EPILEPTOLOGY
  • Place of Presentation: Rhodes, Greece
  • Year and Date: 2010-06-30
• [Presentation] 脳PET画像の部分容積効果補正を目的とした 形態画像の活用 (2009)
  • Author(s): 志田原美保, Charalampos Tsoumpas, Alexander Hammers, Nicolas Boussion, Dimitris Visvikis, 伊藤浩, 木村裕一, 須原哲也, 菅野巖, Federico Turkheimer
  • Organizer: 第49回日本核医学会総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-01
• [Presentation] Functional and structural synergy for resolution recovery and partial volume correction in brain PET (2009)
  • Author(s): Shidahara M, Tsoumpas C, Hammers A, Boussion N, Visvikis D, Ito H, Kimura Y, Suhara T, Kanno I, Turkheimer FE.
  • Organizer: Brain and BrainPET 09
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-07-02