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Structural and functional synergy for quantitative PET images

Research Project

Project/Area Number 21791230
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

SHIDAHARA Miho  National Institute of Radiological Sciences, 大学院・医学系研究科, 講師 (20443070)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords核医学 / 動態解析 / ウェーブレット / PET/MRI / 医用画像処理 / シミュレーション / PET / MRI
Research Abstract

Using a wavelet-based resolution recovery method named SFS-RR (structural and functional synergy for resolution recovery), we have demonstrated that the structural image effectively recovers the true signal in cortical areas (Shidahara et al., 2009). In the current work, we evaluate the performance of the recovery strategy in the case of the quantification of dopaminegic function in striatal regions. The proposed methodology proved effective in the resolution recovery of small structures of brain [^<11>C]raclopride PET images and the improvement is consistent across the anatomical variability of a simulated population.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (6 results)

  • [Journal Article] 陽電子断層撮影装置(PET)を用いた脳神経受容体機能の定量解析2011

    • Author(s)
      志田原美保、田村元
    • Journal Title

      東北大医学部保健学科紀要

      Volume: 20 Pages: 1-16

    • NAID

      120002773806

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Positron emission tomography inter-scanner differences in dopamine D2 receptor binding measured with [11C]FLB457.2010

    • Author(s)
      Kodaka F, Ito H, Shidahara M, Takano H, Takahashi H, Arakawa R, Nakayama K, Suhara T
    • Journal Title

      Ann Nucl Med. 24巻9号

      Pages: 671-677

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Analysis of Dopamine Transporters in Human Brain Using [11C]PE2I and Positron Emission Tomography : Evaluation of Reference Tissue Models.2010

    • Author(s)
      Seki C, Ito H, Ichimiya T, Arakawa R, Ikoma Y, Shidahara M, Maeda J, Takano A, Takahashi H, Kimura Y, Suzuki K, Kanno I, Suhara T
    • Journal Title

      Ann Nucl Med. 24巻4号

      Pages: 249-260

    • NAID

      10026509094

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measurement Error analysis for the determination of dopamine D2 receptor occupancy using agonist radioligand [11C]MNPA.2010

    • Author(s)
      Shidahara M, Ito H, Otsuka T, Ikoma Y, Arakawa R, Kodaka F, Seki C, Takano H, Takahashi H, Turkheimer FE, Kimura Y, Kanno I, Suhara T.
    • Journal Title

      J Cereb Blood Flow & Metab 30巻1号

      Pages: 187-195

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A New Graphic Plot Analysis for Determination of Neuroreceptor Binding in Positron Emission Tomography Studies.2010

    • Author(s)
      Ito H, Yokoi T, Ikoma Y, Shidahara M, Seki C, Naganawa M, Takahashi H, Takano H, Kimura Y, Ichise M, Suhara T.
    • Journal Title

      Neuroimage. 49巻1号

      Pages: 578-586

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Positron emission tomography inter-scanner differences in dopamine D2 receptor binding measure with [11C]FLB4572010

    • Author(s)
      Kodaka F, Ito H, Shidahara M, et al.
    • Journal Title

      Ann Nucl Med

      Volume: 24 Pages: 671-677

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Analysis of Dopamine Transporters in Human Brain Using [11C]PE2I and Positron Emission Tomography2010

    • Author(s)
      Seki C, Ito H, Ichimiya T, et al.
    • Journal Title

      Ann Nucl Med

      Volume: 24 Pages: 249-260

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Error analysis for the determination of dopamine D_2 receptor occupancy using agonist radioliand [11C]MNPA2010

    • Author(s)
      Miho Shidahara, et al.
    • Journal Title

      J Cereb Blood Flow & Metab 30(1)

      Pages: 187-195

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of likelihood estimation in Logan graphical analysis using Maximum A posteriori for Neuroreceptor PET imaging.2009

    • Author(s)
      Shidahara M, Seki C, Naganawa M, Sakata M, Ishikawa M, Ito H, Kanno I, Suhara T, Ishiwata K, Kimura Y.
    • Journal Title

      Ann Nucl Med. 23巻2号

      Pages: 163-171

    • NAID

      10025135723

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] No regional difference in dopamine D2 receptor occupancy by the second-generation antipsychotic drug risperidone in humans : a positron emission tomography study.2009

    • Author(s)
      Ito H, Arakawa R, Takahashi H, Takano H, Okumura M, Otsuka T, Ikoma Y, Shidahara M, Suahra T.
    • Journal Title

      Int J Neurophsychopharmacology. 12巻

      Pages: 667-675

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional and structural synergy for resolution recovery and partial volume correction in brain PET.2009

    • Author(s)
      Shidahara M, Tsoumpas C, Hammers A, Boussion N, Visvikis D, Suhara T, Kanno I, Turkheimer FE.
    • Journal Title

      Neuroimage. 44巻2号

      Pages: 340-348

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional and structural synergy for resolution recovery and partial volume correction in brain PET2009

    • Author(s)
      Miho Shidahara, et al.
    • Journal Title

      Neuroimage 44(2)

      Pages: 340-348

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of likelihood estimation in Logan graphical analysis using Maximum A posteriori for Neuroreceptor PET imaging2009

    • Author(s)
      Miho Shidahara, et al.
    • Journal Title

      Ann Nucl Med 23(2)

      Pages: 163-171

    • NAID

      10025135723

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] [11C]MNPAを用いたドーパミンD2受容体占有率測定における誤差解析2010

    • Author(s)
      志田原美保、伊藤浩、大塚達以, ら, 他10名
    • Organizer
      第50回日本核医学会総会
    • Place of Presentation
      大宮
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Quantitative evaluation of 11C-PIB binding in amyloid precursor protein transgenic mouse brains2010

    • Author(s)
      Seki C, Higuchi M, Tokunaga M, Hattori S, Maruyama M, Shidahara M, Okauchi T, Nakao R, Maeda J, Kimura Y, Kanno I, Suhara T
    • Organizer
      Functional Neuroreceptor Mapping of the Living Brain (NRM2010)
    • Place of Presentation
      Grasgow, UK
    • Year and Date
      2010-07-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Correction Of [11C]Diprenorphine PET Data For The Partial-Volume Effect : Application to Quantification Of Opioid Receptor Binding Following Spontaneous Epileptic Seizures2010

    • Author(s)
      McGinnity CJ, Shidahara M, Keihaninejad S, Riano Barros DA, Gousias IS, Heckemann RA, Koepp MJ, Turkheimer FE, Hammers A
    • Organizer
      Functional Neuroreceptor Mapping of the Living Brain (NRM2010)
    • Place of Presentation
      Grasgow, UK
    • Year and Date
      2010-07-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Quantifiaction of opioid receptor availability following spontaneous epilepticseizures2010

    • Author(s)
      McGinnity CJ, Shidahara M, Keihaninejad S, Riano Barros DA, Gousias IS, Heckemann RA, Koepp MJ, Turkheimer FE, Hammers A
    • Organizer
      9th EUROPEAN CONGRESS ON EPILEPTOLOGY
    • Place of Presentation
      Rhodes, Greece
    • Year and Date
      2010-06-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳PET画像の部分容積効果補正を目的とした 形態画像の活用2009

    • Author(s)
      志田原美保, Charalampos Tsoumpas, Alexander Hammers, Nicolas Boussion, Dimitris Visvikis, 伊藤浩, 木村裕一, 須原哲也, 菅野巖, Federico Turkheimer
    • Organizer
      第49回日本核医学会総会
    • Place of Presentation
      旭川
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Functional and structural synergy for resolution recovery and partial volume correction in brain PET2009

    • Author(s)
      Shidahara M, Tsoumpas C, Hammers A, Boussion N, Visvikis D, Ito H, Kimura Y, Suhara T, Kanno I, Turkheimer FE.
    • Organizer
      Brain and BrainPET 09
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-07-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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