Research Project
Grant-in-Aid for Young Scientists (B)
Recently several studies demonstrated that there is a small fraction in solid tumor which is highly resistant to ionizing radiation and that the radioresistant tumor cells often express some stem cell markers. This small population of cells is characteristic of stem cells and called “cancer stem cell”. It is highly resistant to ionizing radiation and it is suggested that resistance of cancers to both radiation and chemotherapeutic agents can be attributed to the features of the cancer stem cells. The purpose of this study is the analysis of cancer stem-like cells derived from established glioblastoma cell line and radiosensitivity in cancer stem-like cells using X-rays and heavy ion beam. As a result, it has been shown that sub population of human glioblastoma cell line A172 grown in non serum free medium showed cancer stem cell-like property and radioresistance to both X-rays and heavy ion beam.
All 2011 2009
All Presentation (3 results)
