Improvement of pancreatic tissue preservation during organ storage through the introduction of an Islet of Langerhans oxygenation system
| Project/Area Number |
21791239
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
INAGAKI Akiko Tohoku University, 未来科学技術共同研究センター, 助教 (20360224)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵島移植 / 移植・再生医療 / 臓器保存 / 重症糖尿病 |
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| Research Abstract |
Establishing methods to prepare high quality Islets of Langerhans for transplantation is an important subject directly linked to improving transplantation success. This research aims to prevent hypoxic damage to the Islets of Langerhans. We accomplished this by introducing a method to ensure consistent oxygenation from pancreatic organ storage to the completion of pancreatic enzyme treatment. The method involved injecting artificial hemoglobin into the pancreatic ducts to oxygenate the pancreatic tissue during storage. The introduction of oxygenation to the pancreatic ducts via artificial oxygen carriers, as well as the use of hollow fiber pressurization modules within the donor islets clearly improved the output, energy status, and viability of islets and suppressed apoptosis.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Attenuation of the cross-talk between the complement and coagulation cascades by C5a blockade improves early outcomes after intraportal islet transplantation.2010
Author(s)
K Tokodai, M Goto, A Inagaki, W Nakanishi, N Ogawa, K Satoh, N kawagishi, S sekiguchi, B Nosson, N Okada, H Okada, S Satomi.
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Journal Title
Transplantation 90(12)
Pages: 1358-1365
NAID
Related Report
Peer Reviewed
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[Journal Article] Attenuation of the cross-talk between the complement and coagulation cascades by C5a blockade improves early outcomes after intraportal islet transplantation.2010
Author(s)
K Tokodai, M Goto, A Inagaki, W Nakanishi, N Ogawa, K Satoh, N kawagishi, S sekiguchi, B Nosson, N Okads, H Okada, S Satomi.
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Journal Title
Transplantation
Volume: 90(12)
Pages: 1358-65
NAID
Related Report
Peer Reviewed
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