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Improvement of pancreatic tissue preservation during organ storage through the introduction of an Islet of Langerhans oxygenation system

Research Project

Project/Area Number 21791239
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionTohoku University

Principal Investigator

INAGAKI Akiko  Tohoku University, 未来科学技術共同研究センター, 助教 (20360224)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膵島移植 / 移植・再生医療 / 臓器保存 / 重症糖尿病
Research Abstract

Establishing methods to prepare high quality Islets of Langerhans for transplantation is an important subject directly linked to improving transplantation success. This research aims to prevent hypoxic damage to the Islets of Langerhans. We accomplished this by introducing a method to ensure consistent oxygenation from pancreatic organ storage to the completion of pancreatic enzyme treatment. The method involved injecting artificial hemoglobin into the pancreatic ducts to oxygenate the pancreatic tissue during storage. The introduction of oxygenation to the pancreatic ducts via artificial oxygen carriers, as well as the use of hollow fiber pressurization modules within the donor islets clearly improved the output, energy status, and viability of islets and suppressed apoptosis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (21 results)

  • [Journal Article] Attenuation of the cross-talk between the complement and coagulation cascades by C5a blockade improves early outcomes after intraportal islet transplantation.2010

    • Author(s)
      K Tokodai, M Goto, A Inagaki, W Nakanishi, N Ogawa, K Satoh, N kawagishi, S sekiguchi, B Nosson, N Okada, H Okada, S Satomi.
    • Journal Title

      Transplantation 90(12)

      Pages: 1358-1365

    • NAID

      10029678574

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Impact of Ischemic Stress on the Quality of Isolated Pancreatic Islets.2010

    • Author(s)
      M Goto, T Imura, A Inagaki, N Ogawa, H Yamaya, K. Fujimori, Y Kurokawa, S Satomi.
    • Journal Title

      Transplantation Proc 42(6)

      Pages: 2040-2043

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] C5a-Inhibitory Peptide Combined with Gabexate Mesilate Prevents the Instant Blood-Mediated Inflammatory Reaction in a Rat Model of Islet Transplantation.2010

    • Author(s)
      K Tokodai, M Goto, A Inagaki, W Nakanishi, N Okada, H Okada, S Satomi
    • Journal Title

      Transplantation Proc 42(6)

      Pages: 2040-2043

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of the cross-talk between the complement and coagulation cascades by C5a blockade improves early outcomes after intraportal islet transplantation.2010

    • Author(s)
      K Tokodai, M Goto, A Inagaki, W Nakanishi, N Ogawa, K Satoh, N kawagishi, S sekiguchi, B Nosson, N Okads, H Okada, S Satomi.
    • Journal Title

      Transplantation

      Volume: 90(12) Pages: 1358-65

    • NAID

      10029678574

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Impact of Ischemic Stress on the Quality of Isolated Pancreatic Islets. 42(6) : 2040-2043, 2010.2010

    • Author(s)
      M Goto, T Imura, A Inagaki, N Ogawa, H Yamaya, K.Fujimori, Y Kurokawa, S Satomi
    • Journal Title

      Transplantation Proc.

      Volume: 42(6) Pages: 2040-43

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C5a-Inhibitory Peptide Combined with Gabexate Mesilate Prevents the Instant Blood-Mediated Inflammatory Reaction in a Rat Model of Islet Transplantation2010

    • Author(s)
      K Tokodai, M Goto, A Inagaki, W Nakanishi, N Okada, H Okada, S Satomi
    • Journal Title

      Transplantation Proc.

      Volume: 42(6) Pages: 2003-4

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 膵動静脈奇形に起因する急性腹膜炎に対しグラフト保護プロトコールの導入により良好な結果を得た自家膵島移植症例の報告2011

    • Author(s)
      後藤昌史、坂田直昭、山谷英之、元井冬彦、山口賢、猪村武弘、稲垣明子、伊藤経夫、林洋毅、石垣泰、片桐秀樹、長谷川豊、澤田正二郎、廣田衛久、下瀬川徹、関口悟、藤盛啓成、江川新一、海野倫明、里見進
    • Organizer
      第38回日本膵・膵島移植研究会
    • Place of Presentation
      奈良市
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膵動静脈奇形に起因する急性腹膜炎に対しグラフト保護プロトコールの導入により良好な結果を得た自家膵島移植症例の報告2011

    • Author(s)
      後藤昌史、坂田直昭、山谷英之、元井冬彦、山口賢、猪村武弘、稲垣明子、伊藤経夫、林洋毅、石垣泰、片桐秀樹、長谷川豊、澤田正二郎、廣田衛久、下瀬川徹、関口悟、藤盛啓成、江川新一、海野倫明、里見進
    • Organizer
      第38回日本膵・膵島移植研究会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Thioredoxin-1による移植後早期膵島障害の抑制2011年3月4日2011

    • Author(s)
      阿佐美健吾、後藤昌史、猪村武弘、稲垣明子、関口悟、藤盛啓成、淀井淳司、里見進
    • Organizer
      第38回日本膵・膵島移植研究会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-04
    • Related Report
      2010 Final Research Report
  • [Presentation] A Study on the Influence and Control of Ischemic Stress during Pancreas Preservation on Isolated Islets2011

    • Author(s)
      F Zhaoqiang, M Goto, T Imura, A Inagaki, H Yamaya, Y Kurokawa, S Sekiguchi, K Fujimori, J Yodoi, S Satomi
    • Organizer
      第38回日本膵・膵島移植研究会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-04
    • Related Report
      2010 Final Research Report
  • [Presentation] A Study on the Influence and Control of Ischemic Stress during Pancreas Preservation on Isolated Islets2011

    • Author(s)
      F Zhaoqiang, M Goto, T Imura, A Inagaki, H Yamaya, Y Kurokawa, S Sekiguchi, K Fujimori, J Yodoi, S Satomi
    • Organizer
      第38回日本膵・膵島移植研究会
    • Place of Presentation
      奈良市
    • Year and Date
      2011-03-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Thioredoxin-1による移植後早期膵島障害の抑制2011

    • Author(s)
      阿佐美健吾、後藤昌史、猪村武弘、稲垣明子、関口悟、藤盛啓成、淀井淳司、里見進
    • Organizer
      第38回日本膵・膵島移植研究会
    • Place of Presentation
      奈良市
    • Year and Date
      2011-03-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膵島を含有するシート作製方法の検討2011

    • Author(s)
      稲垣明子、後藤昌史、大橋一夫、里見進
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 膵島を含有するシート作製方法の検討2011

    • Author(s)
      稲垣明子、後藤昌史、大橋一夫、里見進
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 現状における臨床グレードの膵島分離用酵素剤の検証2010

    • Author(s)
      後藤昌史、山形洋平、渡邉君子、村山和隆、猪村武弘、稲垣明子、山谷英之、小川則彦、藤盛啓成、黒川良望、里見進
    • Organizer
      第46回日本移植学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2010-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 安全で高性能な新規膵島分離用酵素剤の開発2010

    • Author(s)
      後藤昌史、山形洋平、渡邉君子、村山和隆、猪村武弘、稲垣明子、山谷英之、小川則彦、藤盛啓成、黒川良望、里見進
    • Organizer
      第46回日本移植学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2010-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 安全で高性能な新規膵島分離用酵素剤の開発2010

    • Author(s)
      後藤昌史、山形洋平、渡邉君子、村山和隆、猪村武弘、稲垣明子、山谷英之、小川則彦、藤盛啓成、黒川良望、里見進
    • Organizer
      第46回日本移植学会総会
    • Place of Presentation
      京都府
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 現状における臨床グレードの膵島分離用酵素剤の検証2010

    • Author(s)
      後藤昌史、山形洋平、渡邉君子、村山和隆、猪村武弘、稲垣明子、山谷英之、小川則彦、藤盛啓成、黒川良望、里見進
    • Organizer
      第46回日本移植学会総会
    • Place of Presentation
      京都府
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Interruption of a cross-talk between the complement and coagulation cascades improves early outcomes after intraportal islet transplantation2010

    • Author(s)
      K Tokodai, M Goto, A Inagaki, W Nakanishi, N Okada, H Okada, S Sato
    • Organizer
      XXIII International Congress of The Transplantation Society
    • Place of Presentation
      Vancouver, Canada.
    • Year and Date
      2010-08-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Interruption of a cross-talk between the complement and coagulation cascades improves early outcomes after intraportal islet transplantation2010

    • Author(s)
      K Tokodai, M Goto, A Inagaki, W Nakanishi, N Okada, H Okada, S Satomi
    • Organizer
      XXIII International Congress of The Transplantation Society
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-08-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞シートによる膵島の新規移植方法の検討2010

    • Author(s)
      稲垣明子、後藤昌史、大橋一夫、小林英司、里見進
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-18
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 臨床再開へ向けた膵島分離用酵素剤の比較検討2010

    • Author(s)
      後藤昌史、山形洋平、渡邉君子、村山和隆、猪村武弘、稲垣明子、山谷英之、小川則彦、藤盛啓成、黒川良望、里見進
    • Organizer
      第37回膵・膵島移植研究会
    • Place of Presentation
      宇都宮
    • Year and Date
      2010-03-12
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] The impact of ischemic stress on the quality of isolated pancreatic islets2009

    • Author(s)
      Masafumi Goto, Takehiro Imura, Akiko Inagaki, Norihiko Ogawa, Hideyuki Yamaya, Keisei Fujimori, Yoshimochi Kurokawa, Susumu Satomi.
    • Organizer
      International Pancreas and islet transplant association.
    • Place of Presentation
      Venice, Italy.
    • Year and Date
      2009-10-13
    • Related Report
      2010 Final Research Report
  • [Presentation] A strong candidate approach to prevent the instant blood-mediated inflammatory reaction in clinical islet transplantation2009

    • Author(s)
      Kazuaki Tokodai, Masafumi Goto, Akiko Inagaki, Wataru Nakanishi, Noriko Okada, Hidechika Okada, Susumu Satomi.
    • Organizer
      International Pancreas and islet transplant association.
    • Place of Presentation
      Venice, Italy.
    • Year and Date
      2009-10-13
    • Related Report
      2010 Final Research Report
  • [Presentation] The impact of ischemic stress on the quality of isolated pancreatic islets2009

    • Author(s)
      Masafumi Goto, Takehiro Imura, Akiko Inagaki, Norihiko Ogawa, Hideyuki Yamaya, Keisei Fujimori Yoshimochi Kurokawa, Susumu Satomi
    • Organizer
      International Pancreas and islet transplant association
    • Place of Presentation
      ベニス、イタリア
    • Year and Date
      2009-10-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] A strong candidate approach to prevent the instant blood-mediated inflammatory reaction in clinical islet transplantation2009

    • Author(s)
      Kazuaki Tokodai, Masafumi Goto, Akiko Inagaki, Wataru Nakanishi, Noriko Okada, Hidechika Okada, Susumu Satomi
    • Organizer
      International Pancreas and islet transplant association
    • Place of Presentation
      ベニス、イタリア
    • Year and Date
      2009-10-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 臓器の阻血障害が膵島分離へ及ぼす影響に関する検討2009

    • Author(s)
      後藤昌史、猪村武弘、稲垣明子、小川則彦、山谷英之、Feng Qiang、藤盛啓成、黒川良望、里見進
    • Organizer
      第45回日本移植学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-17
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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