|Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
We showed the specific accumulation of B.longum bacterium injected generally or locally to ischemic organ, and the disappearance of this bacterium from nonischemic organ using ischemic hind limb mouse model, and in cardiac infarction in miniature swine model.
We also showed that this anaerobic bacterial vector administration is generally and locally safe using mouse ischemic model. Anaerobic vector using B. longum bacterium may be an effective strategy for therapeutic neovascularization in patients with ischemic cardiovascular disease.