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Role of muscarinic acetylcholine receptor in the development of transplant arteriosclerosis

Research Project

Project/Area Number 21791247
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

MATSUMOTO Yuji  浜松医科大学, 医学部, 助教 (80397380)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords移植後動脈硬化 / 慢性拒絶 / ムスカリン性ACh受容体 / 炎症細胞 / 遊走
Research Abstract

We investigated the role of muscarinic acetylcholine receptor (mAChR) in the development of transplant arteriosclerosis. Mononuclear leukocytes were isolated from bone-marrow of mAChR deficient mice and wild-type (WT) mice. Cell migration was examined using a Boyden chamber system. Carbachol-induced leukocyte migration was significantly reduced in the cells harvested from mAChR-deficient mice. These results suggest that mAChR-mediated leukocyte migration may play an important role in the development of transplant arteriosclerosis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2012 2011

All Presentation (3 results)

  • [Presentation] M1 and M5 muscarinic acetylcholine receptor-mediated leukocyte migration2012

    • Author(s)
      Kosuke Harada, Yuji Matsumoto, Kazuo Umemura
    • Organizer
      第85回日本薬理学会年会
    • Related Report
      2010 Final Research Report
  • [Presentation] ムスカリン性アセチルコリン受容体を介した白血球遊走2011

    • Author(s)
      松本祐直
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-03-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Muscarinic acetylcholine receptor-mediated leukocyte migration2011

    • Author(s)
      Kosuke Harada, Yuji Matsumoto, Kazuo Umemura
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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