The research for immunotherapy used by gd T cells

• Project/Area Number: 21791249
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Kyoto University
• Principal Investigator: YOSHIZAWA Atsushi Kyoto University, 医学研究科, 特定助教 (60457984)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肝移植 / 移植免疫 / γδT細胞 / 免疫寛容

Research Abstract

In this study, we found the increase of γδ T cells in the peripheral blood from pediatric living donor liver transplantation recipients. The feature of gd T cells from recipients is the oligoglonal expansion ; the TCR of γδ T cell showed Vd1 TCR and the variable region of Vδ1 chain showed mnoclonality. We succeeded the expansion of γδ T cell from PBMC of healthy volunteers in vitro, and those T cells showed the immunosuppressive activity. These immunosuppressive T cells will be applied to new immunosuppressive therapy by transfer of the cells.