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HOXB9 promotes the acquisition of tumorigenic phenotypes in breast cancer

Research Project

Project/Area Number 21791260
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionKeio University

Principal Investigator

HAYASHIDA Tetsu  Keio University, 医学部, 助教 (80327543)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords乳癌 / HOXB9 / EMT / 予後因子 / 微小環境 / 血管新生 / TGFβ / 癌幹細胞 / TGF β
Research Abstract

In this study, we demonstrated that HOXB9, a member of homeobox genes, expression promoted tumor neovascularization and metastasis in in vitro and in vivo assay. These findings imply that overexpression of HOXB9 contributes to tumor progression through activation of signaling pathways that alter both tumor-specific cell fates like epithelial-mesenchymal transition (EMT) and tumor-stromal microenvironment. Moreover, Clinical outcomes were significantly different between the patients with HOXB9 positive and negative, suggesting HOXB9 might be a significant prognostic factor for clinical outcomes in breast cancer patient.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (12 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Cooperation of cancer stem cell properties and epithelial-mesenchymal transition in the establishment of breast cancer metastasis.2011

    • Author(s)
      Hayashida T, Jinno H, Kitagawa Y, Kitajima M.
    • Journal Title

      J Oncol.

      Pages: 591427-591427

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooperation of cancer stem cell properties and epithelial-mesenchymal transition in the establishment of breast cancer metastasis.2011

    • Author(s)
      Tetsu Hayashida
    • Journal Title

      Journal of Oncology

      Volume: Vol.2011 Pages: 591427-591427

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis.2010

    • Author(s)
      Hayashida T, Takahashi F, Chiba N, et al.
    • Journal Title

      Proc Natl Acad Sci USA. 107(3)

      Pages: 1100-1105

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 消化器癌とEMT(epithelial-mesenchymal transition)2010

    • Author(s)
      林田哲
    • Journal Title

      Surgery Frontier

      Volume: 17 Pages: 147-151

    • Related Report
      2010 Annual Research Report
  • [Presentation] HOXB9 Expression as a New Independent Prognostic Factor in Human Breast Cancer.2010

    • Author(s)
      Seki H
    • Organizer
      San Antonio Breast Cancer Symposium
    • Place of Presentation
      米国San Antonio
    • Year and Date
      2010-12-11
    • Related Report
      2010 Final Research Report
  • [Presentation] EMT制御を通じた癌幹細胞抑制の可能性の検討2010

    • Author(s)
      林田哲
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 転写因子HOXB9による細胞悪性化及び微小環境の変化を介した乳癌進展メカニズムの解析2010

    • Author(s)
      林田哲
    • Organizer
      第69回日本癌学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 転写因子HOXB9による細胞悪性化及び微小環境の変化を介した乳癌進展メカニズムの解析2010

    • Author(s)
      林田哲
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大腸癌進展におけるHOXB9遺伝子発現の検討2010

    • Author(s)
      平田玲, 林田哲, 長谷川博俊, ら
    • Organizer
      第19回日本がん転移学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2010-06-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 転写因子HOXB9によるTGFβ経路活性及び腫瘍血管新生促進による乳癌悪性化メカニズムの検討2010

    • Author(s)
      林田哲
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-08
    • Related Report
      2010 Final Research Report
  • [Presentation] HOXB9, a gene overexpressed in breast cancer, induces angiogenesis, invasion, and lung metastasis2010

    • Author(s)
      Tetsu Hayashida
    • Organizer
      7th European Breast Cancer Conference
    • Place of Presentation
      スペイン・バルセロナ
    • Year and Date
      2010-03-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Overexpression of HOXB9 in breast cancer mediates induction of EMT, tumor angiogenesis, and lung metastasis.2010

    • Author(s)
      Tetsu Hayashida
    • Organizer
      AACR/JCA Joint Conference
    • Place of Presentation
      米国ハワイ
    • Year and Date
      2010-02-08
    • Related Report
      2010 Final Research Report
  • [Presentation] HOXB9 Promotes the Acquisition of Tumorigenic Phenotypes in Mammary Epithelial Cells2009

    • Author(s)
      Tetsu Hayashida
    • Organizer
      San Antonio Breast Cancer Symposium
    • Place of Presentation
      米国San Antonio
    • Year and Date
      2009-12-13
    • Related Report
      2010 Final Research Report
  • [Presentation] HOXB9 Promotes the Acquisition of Tumorigenic Phenotypes in Mammary Epithelial Cells2009

    • Author(s)
      林田哲
    • Organizer
      San Antonio Breast Cancer Symposium
    • Place of Presentation
      San Antonio(米国)
    • Year and Date
      2009-12-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 乳癌におけるEMTと癌幹細胞の関連性の追求2009

    • Author(s)
      林田哲
    • Organizer
      第18回日本がん転移学会学術集会
    • Place of Presentation
      旭川
    • Year and Date
      2009-07-23
    • Related Report
      2010 Final Research Report
  • [Presentation] EMT誘導因子hoxb9の機能解析を基にした新しい乳癌進展阻害法の検討2009

    • Author(s)
      林田哲
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-02
    • Related Report
      2010 Final Research Report
  • [Book] 消化器癌とEMT(epithelial-mesenchymal transition)(Surgery Frontier 17(2))2010

    • Author(s)
      林田哲, 神野浩光, 北川雄光
    • Publisher
      メディカルレビュー社
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等 なし

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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