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A research for new cancer vaccine with heat shock protein for esophageal cancer

Research Project

Project/Area Number 21791268
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionChiba University

Principal Investigator

AKUTSU Yasunori  千葉大学, 大学院・医学研究院, 講師 (00375677)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords食道癌 / ヒートショックプロテイン / gp96 / ヒートショックプロティン
Research Abstract

We developed a procedure for extraction of tumor-derived HSP-peptide complex from from tumor using mouse squamous cell carcinoma SCCVII. Purification was carried out according to Pramod K. Srivastav's method (METHODS : A Companion to Methods in Enzymology 12, 165.171 (1997)). Then using clinical specimens, we evaluated the expression of gp96 and prognosis of esophageal cancer patients that underwent surgery and analyzed a correlation between gp96 expression and surgical outcome.
In surgical specimens, 73% of all cases expressed gp96. A positive rate of lymph node metastases was higher in cases with negative gp96 expression. By univariate analysis, gp96 positivity indicated good survival compared to negative cases (p=0.049). By multivariate analysis, negativity for gp96 was an independent prognostic factor(Hazard ratio : 2.6, p=0.04). The number of metastatic lymph nodes was much higher in gp96 negative cases. These results indicated that gp96 can be a useful biomarker for esophageal cancer. These result has been published in a scientific journal.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Correlation between gp96 expression and the surgical outcome in patients with esophageal squamous cell carcinoma2011

    • Author(s)
      Y. Akutsu, et al
    • Journal Title

      Annals of Surgical Oncology

      Volume: 18 Pages: 832-837

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] COX2 expression predicts resistance to chemoradiotherapy in esophageal squamous cell carcinoma2011

    • Author(s)
      Y. Akutsu, et al
    • Journal Title

      Annals of Surgical Oncology

      Volume: 18 Pages: 2946-51

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] COX2 Expression Predicts Resistance to Chemoradiotherapy in Esophageal Squamous Cell Carcinoma2011

    • Author(s)
      Y.Akutsu, et al.
    • Journal Title

      Annals of Surgical Oncology

      Volume: 18 Pages: 131-138

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 食道扁平上皮癌におけるリンパ節転移と免疫マーカーとしてのgp96発現の検討2011

    • Author(s)
      阿久津泰典
    • Organizer
      第65回日本食道学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2011-09-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Correlation between gp96 expression and the surgical outcome in patients with esophageal squamous cell carcinoma2011

    • Author(s)
      Akutsu Y., et al
    • Organizer
      International Surgical Week 2011 (ISDS)
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-08-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食道癌における免疫学的バイオマーカーとしてのgp96発現の意義2011

    • Author(s)
      阿久津泰典
    • Organizer
      第21回癌免疫外科研究会
    • Place of Presentation
      和歌山
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Antitumor effect for squamous cell carcinoma mediated by heat shock protein gp962010

    • Author(s)
      Y. Akutsu, et al
    • Organizer
      2010年AACR-JCA合同会議
    • Place of Presentation
      aikoloa, Hawai (U.S.A.)
    • Year and Date
      2010-02-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Antitumor effect for squamous cell carcinoma mediated by heat shock protein gp962010

    • Author(s)
      Akutsu Y, et al
    • Organizer
      2010年AACR-JCA合同会議
    • Place of Presentation
      Waikoloa, Hawai(U.S.A.)
    • Year and Date
      2010-02-06
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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