| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
The Cecal ligation and puncture (CLP) model is a clinical septicemic and infection model. We gave antimicrobial peptide and examined effect of treatment on CLP model. Control group was CLP control group. Peptide group was injected intraperitoneally with antimicrobial peptides before closing the abdomen. In the peptide group, the survival days were significantly prolonged as compared with control group. IL-6 and TNF-α and endotoxin levels were low level in the peptide group than the control group. Thus, not only we significantly prolonged the survival days by the administration to CLP model, but also the antimicrobial peptide controlled inflammatory reaction, and there was thought to be effect of treatment.
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