Protective effect of antimicrobial peptides based on the beetle defensins on Artificial blood vessel infection
| Project/Area Number |
21791318
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Gifu University |
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Principal Investigator |
NACHI Sho Gifu University, 医学部附属病院, 医員 (30452155)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 外科 / 感染制御 / 抗菌ペプチド |
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| Research Abstract |
The Cecal ligation and puncture (CLP) model is a clinical septicemic and infection model. We gave antimicrobial peptide and examined effect of treatment on CLP model. Control group was CLP control group. Peptide group was injected intraperitoneally with antimicrobial peptides before closing the abdomen. In the peptide group, the survival days were significantly prolonged as compared with control group. IL-6 and TNF-α and endotoxin levels were low level in the peptide group than the control group. Thus, not only we significantly prolonged the survival days by the administration to CLP model, but also the antimicrobial peptide controlled inflammatory reaction, and there was thought to be effect of treatment.
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Report
(3 results)
Research Products
(4 results)
