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Development of evaluation and treatment of marginal donor lungs and deceased donor lungs.

Research Project

Project/Area Number 21791320
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionKyoto University

Principal Investigator

CHEN Fengshi  Kyoto University, 医学研究科, 助教 (00452334)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsマージナルドナー肺 / 心臓死ドナー肺 / 肺移植 / ドナー / マージナルドナー / 心臓死ドナ / 体外回路
Research Abstract

To encounter the donor shortage in lung transplantation, marginal donor lungs and donor lungs after cardiac death have recently been utilized. It would be very important to evaluate such donor lungs before lung transplantation objectively for the safe use of these organs. Thus, the principle investigator established a model, by which the quality of the donor lungs could be assessed, using middle to large animal ex vivo lung perfusion (EVLP) circuit. Furthermore, we demonstrated the results in which EVLP itself could probably resuscitate the marginal donor lungs and donor lungs after cardiac death. From now on, we will accumulate more data regarding EVLP to pursue its possibility and also try to treat the injured donor lungs by administering several drugs during EVLP.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (34 results)

All 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (20 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Normothermic ex vivo lung perfusion in clinical lung transplantation.2011

    • Author(s)
      Cypel M, Yeung JC, Liu M, Anraku M, Chen F, Karolak W, Sato M, Laratta J, Azad S, Madonik M, Chow CW, Chaparro C, Hutcheon M, Singer LG, Slutsky AS, Yasufuku K, de Perrot M, Pierre AF, Waddell TK, Keshavjee S.
    • Journal Title

      N Engl J Med. 364(15)

      Pages: 1431-1440

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of ET-Kyoto solution and Perfadex solution in apig ex vivo lung perfusion model : Impact of potassium level.2011

    • Author(s)
      Okamoto T, Chen F, et al.
    • Journal Title

      Transplantation Proceedings

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety of normothermic ex vivo lung perfusion in clinical lung transplantation.2011

    • Author(s)
      Cypel M, Chen F, et al.
    • Journal Title

      N Eng J Med

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of an ex-vivo lung perfusion model using non-heart-beating large pigs.2010

    • Author(s)
      Okamoto T, Chen F, Zhang J, Yamada T, Nakayama E, Morikawa H, Bando T, Date H.
    • Journal Title

      Transplant Proc 42(5)

      Pages: 1598-1601

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of ET-Kyoto solution and Perfadex solution in a pig ex vivo lung perfusion model : Impact of potassium level.2010

    • Author(s)
      OkamotoT, Chen F, Zhang J, Choi H, Yamada T, Morikawa H, Nakayama E, Bando T, Date H.
    • Journal Title

      Organ Transplant. 15

      Pages: 2-2

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of an ex-vivo lung perfusion model using non-heart-beating large pigs.2010

    • Author(s)
      Okamoto T, Chen F, et al.
    • Journal Title

      Transplantation Proceedings

      Volume: 42 Pages: 1598-1601

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Initial experience with lung donation after cardiocirculatory death in Canada.2009

    • Author(s)
      Cypel M, Sato M, Yildirim E, Karolak W, Chen F, Yeung J, Boasquevisque C, Leist V, Singer LG, Yasufuku K, DePerrot M, Waddell TK, Keshavjee S, Pierre A.
    • Journal Title

      J Heart Lung Transplant 28

      Pages: 753-758

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肺移植の最前線:新しいドナーソースからの肺移植-心臓死ドナーを中心としたマージナルドナーからの肺移植-2009

    • Author(s)
      陳豊史、伊達洋至
    • Journal Title

      移植 44

      Pages: 415-420

    • NAID

      10026246670

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Initial experience with lung donation after cardiocirculatory death in Canada.2009

    • Author(s)
      Cypel M, Chen F, Keshavjee S, et al.
    • Journal Title

      J Heart Lung Transplant 28

      Pages: 753-758

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The establishment of an ex-vivo lung perfusion model using non-heart-beating large pigs.

    • Author(s)
      Okamoto T, Chen F, Zhang J, et al.
    • Journal Title

      Transplant Proc (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 常温肺体外灌流一normothermic ex-vo lung perfusion (EVLP)一による心停止ドナー肺の回復2011

    • Author(s)
      中島大輔、山田徹、陳豊史、阪本仁、大角明宏、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
    • Organizer
      第27回肺および心肺移植研究会
    • Place of Presentation
      岡山市
    • Year and Date
      2011-01-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 常温肺体外灌流一normothermic ex-vo lung perfusion (EVLP)一による心停止ドナー肺の回復。2011

    • Author(s)
      中島大輔、陳豊史、山田徹、阪本仁、大角明宏、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
    • Organizer
      第28回日本呼吸器外科学会総会,O06-04
    • Place of Presentation
      大分
    • Related Report
      2010 Final Research Report
  • [Presentation] Challenge in size matching in pediatric single lobar lung transplantation using three-dimensional computed tomographic volumetry.2011

    • Author(s)
      Chen F, Ishii H, Shoji T, Fujinaga T, Sonobe M, Ikeda T, Nakata T, Nakajima D, Sakamoto J, Osumi A, Sakai H, Bando T, Kubo T, Date H.
    • Organizer
      30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract#702
    • Place of Presentation
      San Diego
    • Related Report
      2010 Final Research Report
  • [Presentation] Reconditioning of lungs from non-heart-beating donors with normothermic ex vivo lung perfusion.2011

    • Author(s)
      Nakajima D, Yamada T, Chen F, Sakamoto J, Ohsumi A, Fujinaga T, Shoji T, Sakai H, Bando T, Date H.
    • Organizer
      30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract#91
    • Place of Presentation
      San Diego
    • Related Report
      2010 Final Research Report
  • [Presentation] Reconditioning of lungs with pulmonary edema in ex vivo lung perfusion circuit.2011

    • Author(s)
      Yamada T, Nakajima D, Sakamoto J, Chen F, Okamoto T, Ohsumi A, Fujinaga T, Shoji T, Sakai H, Bando T, Date H.
    • Organizer
      30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract#422
    • Place of Presentation
      San Diego
    • Related Report
      2010 Final Research Report
  • [Presentation] イヌ心停止ドナー肺移植モデルにおける臓器摘出前の換気によるグラフト肺保護効果2010

    • Author(s)
      阪本仁、山田徹、陳豊史、中島大輔、高橋鮎子、里田直樹、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
    • Organizer
      第46回日本移植学会総会,045
    • Place of Presentation
      京都
    • Year and Date
      2010-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Intermediate-term outcomes of the living donor lobar lung transplantation following hematopoietic stem cell transplantation from the same donor.2010

    • Author(s)
      Chen F, et al.
    • Organizer
      XXIII International Congress of The Transplantation Society
    • Place of Presentation
      Vancouver
    • Year and Date
      2010-08-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hypothermic ex vivo perfusion prevents ischemia reperfusion injury in rat lungs from non-heart-beating donors.2010

    • Author(s)
      Nakajima D, Chen F, et al.
    • Organizer
      XXIII International Congress of The Transplantation Society
    • Place of Presentation
      Vancouver
    • Year and Date
      2010-08-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Protective effect of ventilation before organ procurement on graft lungs donated after cardiac death in a canine lung transplantation model.2010

    • Author(s)
      Sakamoto J, Chen F, et al.
    • Organizer
      XXIII International Congress of The Transplantation Society
    • Place of Presentation
      Vancouver
    • Year and Date
      2010-08-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 中動物肺移植モデルを用いた、摘出前換気による心停止ドナー肺の保護効果2010

    • Author(s)
      阪本仁、山田徹、陳豊史、中島大輔、菊地柳太郎、小島史嗣、大角明宏、高橋鮎子、里田直樹、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
    • Organizer
      第63回日本胸部外科学会定期学術集会,OP-07
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Protective effect of ventilation before organ procurement on graft lungs donated after cardiac death in a canine lung2010

    • Author(s)
      Sakamoto J, Yamada T, Chen F, Nakajima D, Kikuchi R, Kojima F, Osumi A, Takahashi A, Satoda N, Fujinaga T, Shoji T, Sakai H, Bando T, Date H.
    • Organizer
      transplantation model.O11.04 XXIII International Congress of The Transplantation Society Vancouver
    • Place of Presentation
      Canada
    • Related Report
      2010 Final Research Report
  • [Presentation] Ex vivo lung perfusion in clinical lung transplantation-The "HELP" trial.2010

    • Author(s)
      Cypel M, Yeung JC, de Perrot M, Karolak W, Chen F, Sato M, Azad S, Madonik M, Hutcheon M, Chaparro C, Chow CW, Yasufuku K, Pierre A, Singer LG, Waddell TK, Keshavjee S.
    • Organizer
      30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract #258
    • Place of Presentation
      Chicago
    • Related Report
      2010 Final Research Report
  • [Presentation] 長時間常温体外循環(Ex vivo lung perfusion)の確立2010

    • Author(s)
      中島大輔、山田徹、阪本仁、陳豊史、岡本俊宏、張吉天、高橋鮎子、里田直樹、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
    • Organizer
      日本呼吸器外科学会総会,P017-05
    • Place of Presentation
      仙台
    • Related Report
      2010 Final Research Report
  • [Presentation] Novel surgical training system of lung transplantation in continuous pulmonary perfusion and ventilation using pig heart-lung blocks.2010

    • Author(s)
      Okamoto T, Yamada T, Morikawa H, Nakayama E, Satoda N, Zhang J, Takahashi A, Zhao X, Chen F, Fujinaga T, Shoji T, Sakai H, Bando T, Date H.
    • Organizer
      30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract #430
    • Place of Presentation
      Chicago
    • Related Report
      2010 Final Research Report
  • [Presentation] 心臓死ドナーからの肺移植:トロント大学における経験2009

    • Author(s)
      陳豊史、Marcelo Cypel, Wojtek Karolak, Shaf Keshavjee, Andrew Pierre, 板東徹、伊達洋至
    • Organizer
      第62回日本胸部外科学会定期学術集会,O-149
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 心臓死ドナーからの肺移植:トロント大学における経験2009

    • Author(s)
      陳豊史
    • Organizer
      第62回日本胸部外科学会定期学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺移植Clinical fellowを通して感じたこと。2009

    • Author(s)
      陳豊史
    • Organizer
      第62回日本胸部外科学会定期学術集会,W1-5
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-11
    • Related Report
      2010 Final Research Report
  • [Presentation] マージナルドナー肺心臓死ドナー肺の新しい評価と保護法。2009

    • Author(s)
      陳豊史、岡本俊宏、山田徹、張吉天、青山晃博、藤永卓司、森川洋匡、高橋鮎子、里田直樹、庄司剛、阪井宏彰、板東徹、伊達洋至
    • Organizer
      第45回日本移植学会総会,S5-3
    • Place of Presentation
      東京
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] How the cause of death affects the quality of DCD donor lung?-An experimental study-2009

    • Author(s)
      T.Yamada, F.Chen, et al.
    • Organizer
      29th Annual Meeting of the International Society for Heart and Lung Transplantation
    • Place of Presentation
      Paris France
    • Related Report
      2009 Annual Research Report
  • [Presentation] Normothermic human ex vivo lung perfusion (EVLP) for improved assessment of extended criteria donor lungs for transplantation2009

    • Author(s)
      Cypel M, Chen F, Keshavjee S, et al.
    • Organizer
      29th Annual Meeting of the International Society for Heart and Lung Transplantation
    • Place of Presentation
      Paris France
    • Related Report
      2009 Annual Research Report
  • [Book] -心臓死ドナーを中心としたマージナルドナーからの肺移植-(肺移植の最前線:新しいドナーソースからの肺移植)(移植)(44)2009

    • Author(s)
      陳豊史、伊達洋至
    • Publisher
      へるす出版
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.thoracic-kyoto-u.gr.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.thoracic-kyoto-u.gr.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.thoracic-kyoto-u.gr.jp/

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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