In situ analysis of crossbridge dynamics in failing heart model of rat using X-ray technique
| Project/Area Number |
21791330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
TAMURA Yamato Nara Medical University, 医学部, 研究員 (20382301)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 化学物理 / 加速器 / 心不全 / X線解析 |
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| Research Abstract |
This study was aimed for the development of the method to give heart failure a diagnosis by observing dynamics of the molecule nano-order using SPring-8. We paid attention to particularly myocardial contractile protein and analyzed actin-myosin interaction and lattice spacing between myosin filaments used the rats which maintained complicated form and a multiplex compensation mechanism and the heart failure model.
We performed the measurement of the hypertrophic heart model by isoproterenol, analyzed crossbridge dynamics in the diastolic phase and the contraction phase and of the hypertrophic heart and evaluated the failing heart.
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Report
(3 results)
Research Products
(11 results)
