Analysis of functional association between estrogen receptor and EGFR in lung cancer and possibility of therapeutic target

• Project/Area Number: 21791339
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: NOSE Naohiro University of Occupational and Environmental Health, Japan, 医学部, 非常勤医師 (50461554)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: EGFR / 肺癌 / 肺腺癌

Research Abstract

A strong expression of ER beta predicts a good clinical outcome for patients with adenocarcinoma of the lung after treatment with EGFR-TKI. This suggests that the expression status of ER beta can be a candidate surrogate marker for EGFR-TKI treatment of patients with adenocarcinoma of the lung.

Research Products

• [Journal Article] Expression of estrogen receptor beta predicts a clinical response and longer progression-free survival after treatment with EGFR-TKI for adenocarcinoma of the lung. (2011)
  • Author(s): Nose N
  • Journal Title: Lung Cancer Volume: (in press)
  • Peer Reviewed
• [Journal Article] 部分肺静脈還流異常を合併した肺癌の一切除例 (2010)
  • Author(s): 近石泰弘, 能勢直弘, 市来嘉伸, 永島明, 安元公正
  • Journal Title: 日本呼吸器外科学会雑誌 24(4) Pages: 704-709
  • NAID: 10026475650
  • Peer Reviewed
• [Journal Article] Acquired resistance to gefitinib : the contribution of mechanisms other than the T790M, MET, and HGF status. (2010)
  • Author(s): Onitsuka T, Uramoto H, Nose N.・Takenoyama M, Hanagiri T, Sugio K, Yasumoto K
  • Journal Title: Lung Cancer 68(2) Pages: 198-203
  • Peer Reviewed
• [Journal Article] Acquired resistance to gefitinib : the contribution of mechanisms other than the T790M, MET, and HGF status. (2010)
  • Author(s): Onitsuka T
  • Journal Title: Lung Cancer Volume: 68 Pages: 198-203
  • Peer Reviewed
• [Journal Article] 部分肺静脈還流異常を合併した肺癌の一切除例 (2010)
  • Author(s): 近石泰弘
  • Journal Title: 日本呼吸器外科学会雑誌 Volume: 24 Pages: 704-709
  • Peer Reviewed
• [Journal Article] Gefitinib and a ventriculo-peritoneal shunt to manage carcinomatous meningitis from non-small-cell lung cancer : report of two cases. (2009)
  • Author(s): So T, Inoue M, Chikaishi Y, Nose N, Sugio K, Yasumoto K
  • Journal Title: Surg Today 39 Pages: 598-602
  • NAID: 10025133363
  • Peer Reviewed
• [Journal Article] Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung. (2009)
  • Author(s): Nose N, Sugio K, Oyama T, Nozoe T, Uramoto H, Iwata T, Onitsuka T, Yasumoto K
  • Journal Title: J Clin Oncol 27(3) Pages: 411-417
  • Peer Reviewed
• [Journal Article] Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung (2009)
  • Author(s): Nose, N
  • Journal Title: J Clin Oncol 27 Pages: 411-417
  • Peer Reviewed
• [Journal Article] Gefitinib and a ventriculo-peritoneal shunt to manage carcinomatous meningitis from non-small-cell lung cancer : report of two cases (2009)
  • Author(s): So, T
  • Journal Title: Surg Today 39 Pages: 598-602
  • Peer Reviewed
• [Journal Article] Expression of estrogen receptor beta predicts a clinical response and longer progression-free survival after treatment with EGFR-TKI for adenocarcinoma of the lung.
  • Author(s): Nose N, Uramoto H, Iwata T, Hanagiri T, Yasumoto K
  • Journal Title: Lung Cancer in press
  • Peer Reviewed
• [Presentation] 肺尖部胸壁浸潤肺癌手術症例の検討 (2010)
  • Author(s): 市来嘉伸, 近石泰弘, 能勢直弘, 永島明, 安元公正
  • Organizer: 第27回日本呼吸器外科学会総会
  • Place of Presentation: 仙台
• [Presentation] 胸骨正中経路左肺全摘術における心臓脱転の工夫 (2010)
  • Author(s): 関村敦, 吉松隆, 宗哲哉, 能勢直弘, 小山倫浩, 安元公正
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島
• [Presentation] 肺尖部胸壁浸潤肺癌手術症例の検討 (2010)
  • Author(s): 市来嘉伸
  • Organizer: 第27回 日本呼吸器外科学会総会
  • Place of Presentation: 仙台国際センター(仙台市)
• [Presentation] 胸骨正中経路左肺全摘術における心臓脱転の工夫 (2010)
  • Author(s): 関村敦
  • Organizer: 第51回 日本肺癌学会総会
  • Place of Presentation: 広島国際会議場(広島市)
• [Presentation] Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung. (2009)
  • Author(s): 能勢直弘
  • Organizer: 第27回産業医科大学学会総会
  • Place of Presentation: 北九州
  • Year and Date: 2009-10-06
• [Presentation] Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung (2009)
  • Author(s): 能勢直弘
  • Organizer: 第27回 産業医科大学学会総会
  • Place of Presentation: 産業医科大学(北九州市)
  • Year and Date: 2009-10-06
• [Presentation] 肺原発Epithelioid Hemangioendotheliomaの一例 (2009)
  • Author(s): 能勢直弘, 近石泰弘, 市来嘉伸, 永島明
  • Organizer: 第63回日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
  • Place of Presentation: 北九州
• [Presentation] 非小細胞肺癌術後脳転移に対する治療成績の検討 (2009)
  • Author(s): 能勢直弘, 横山えりな, 小野憲司, 永島明
  • Organizer: 第26回日本呼吸器外科学会総会
  • Place of Presentation: 北九州
• [Presentation] 非小細胞肺癌術後脳転移に対する治療成績の検討 (2009)
  • Author(s): 能勢直弘
  • Organizer: 第26回 日本呼吸器外科学会総会
  • Place of Presentation: 西日本総合展示場, 他(北九州市)
• [Presentation] 肺原発 Epithelioid Hemangioendothelioma の一例 (2009)
  • Author(s): 能勢直弘
  • Organizer: 第63回 日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
  • Place of Presentation: 北九州国際会議場(北九州市)