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Analysis of functional association between estrogen receptor and EGFR in lung cancer and possibility of therapeutic target

Research Project

Project/Area Number 21791339
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

NOSE Naohiro  University of Occupational and Environmental Health, Japan, 医学部, 非常勤医師 (50461554)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsEGFR / 肺癌 / 肺腺癌
Research Abstract

A strong expression of ER beta predicts a good clinical outcome for patients with adenocarcinoma of the lung after treatment with EGFR-TKI. This suggests that the expression status of ER beta can be a candidate surrogate marker for EGFR-TKI treatment of patients with adenocarcinoma of the lung.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (10 results)

  • [Journal Article] Expression of estrogen receptor beta predicts a clinical response and longer progression-free survival after treatment with EGFR-TKI for adenocarcinoma of the lung.2011

    • Author(s)
      Nose N
    • Journal Title

      Lung Cancer

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 部分肺静脈還流異常を合併した肺癌の一切除例2010

    • Author(s)
      近石泰弘, 能勢直弘, 市来嘉伸, 永島明, 安元公正
    • Journal Title

      日本呼吸器外科学会雑誌 24(4)

      Pages: 704-709

    • NAID

      10026475650

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acquired resistance to gefitinib : the contribution of mechanisms other than the T790M, MET, and HGF status.2010

    • Author(s)
      Onitsuka T, Uramoto H, Nose N.・Takenoyama M, Hanagiri T, Sugio K, Yasumoto K
    • Journal Title

      Lung Cancer 68(2)

      Pages: 198-203

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acquired resistance to gefitinib : the contribution of mechanisms other than the T790M, MET, and HGF status.2010

    • Author(s)
      Onitsuka T
    • Journal Title

      Lung Cancer

      Volume: 68 Pages: 198-203

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 部分肺静脈還流異常を合併した肺癌の一切除例2010

    • Author(s)
      近石泰弘
    • Journal Title

      日本呼吸器外科学会雑誌

      Volume: 24 Pages: 704-709

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gefitinib and a ventriculo-peritoneal shunt to manage carcinomatous meningitis from non-small-cell lung cancer : report of two cases.2009

    • Author(s)
      So T, Inoue M, Chikaishi Y, Nose N, Sugio K, Yasumoto K
    • Journal Title

      Surg Today 39

      Pages: 598-602

    • NAID

      10025133363

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung.2009

    • Author(s)
      Nose N, Sugio K, Oyama T, Nozoe T, Uramoto H, Iwata T, Onitsuka T, Yasumoto K
    • Journal Title

      J Clin Oncol 27(3)

      Pages: 411-417

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung2009

    • Author(s)
      Nose, N
    • Journal Title

      J Clin Oncol 27

      Pages: 411-417

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gefitinib and a ventriculo-peritoneal shunt to manage carcinomatous meningitis from non-small-cell lung cancer : report of two cases2009

    • Author(s)
      So, T
    • Journal Title

      Surg Today 39

      Pages: 598-602

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of estrogen receptor beta predicts a clinical response and longer progression-free survival after treatment with EGFR-TKI for adenocarcinoma of the lung.

    • Author(s)
      Nose N, Uramoto H, Iwata T, Hanagiri T, Yasumoto K
    • Journal Title

      Lung Cancer in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 肺尖部胸壁浸潤肺癌手術症例の検討2010

    • Author(s)
      市来嘉伸, 近石泰弘, 能勢直弘, 永島明, 安元公正
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台
    • Related Report
      2010 Final Research Report
  • [Presentation] 胸骨正中経路左肺全摘術における心臓脱転の工夫2010

    • Author(s)
      関村敦, 吉松隆, 宗哲哉, 能勢直弘, 小山倫浩, 安元公正
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Related Report
      2010 Final Research Report
  • [Presentation] 肺尖部胸壁浸潤肺癌手術症例の検討2010

    • Author(s)
      市来嘉伸
    • Organizer
      第27回 日本呼吸器外科学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胸骨正中経路左肺全摘術における心臓脱転の工夫2010

    • Author(s)
      関村敦
    • Organizer
      第51回 日本肺癌学会総会
    • Place of Presentation
      広島国際会議場(広島市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung.2009

    • Author(s)
      能勢直弘
    • Organizer
      第27回産業医科大学学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2009-10-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung2009

    • Author(s)
      能勢直弘
    • Organizer
      第27回 産業医科大学学会総会
    • Place of Presentation
      産業医科大学(北九州市)
    • Year and Date
      2009-10-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺原発Epithelioid Hemangioendotheliomaの一例2009

    • Author(s)
      能勢直弘, 近石泰弘, 市来嘉伸, 永島明
    • Organizer
      第63回日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] 非小細胞肺癌術後脳転移に対する治療成績の検討2009

    • Author(s)
      能勢直弘, 横山えりな, 小野憲司, 永島明
    • Organizer
      第26回日本呼吸器外科学会総会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] 非小細胞肺癌術後脳転移に対する治療成績の検討2009

    • Author(s)
      能勢直弘
    • Organizer
      第26回 日本呼吸器外科学会総会
    • Place of Presentation
      西日本総合展示場, 他(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺原発 Epithelioid Hemangioendothelioma の一例2009

    • Author(s)
      能勢直弘
    • Organizer
      第63回 日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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