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Molecular mechanisms associated with 1p 19q loss of heterozygosity in oligodendroglioma

Research Project

Project/Area Number 21791347
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionSaitama Medical University (2010)
The University of Tokyo (2009)

Principal Investigator

KOGA Tomoyuki  埼玉医科大学, 医学部, 助教 (40456124)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脳腫瘍 / 乏突起神経膠腫 / 染色体異常 / MYT1L / 神経膠腫 / myelin transcription factor 1-like / 遺伝子発現 / 治療反応性 / 予後
Research Abstract

Oligodendrogliomas with 1p19q loss of heterozygosity respond well to chemotherapy compared with those without. However, the molecular mechanisms associated with this chromosomal abnormality are not well known. Based on the results of our previous study, we have targeted a transcriptional factor, myelin transcription factor 1-like (MYT1L). We have performed RT-PCR. Expression level of MYT1L was higher in oligodendrogliomas with 1p19q loss of heterozygosity. These results suggested that the expression of MYT1L is associated with chromosomal change in oligodendrogliomas and possibly useful as diagnostic tool of these tumors.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (49 results)

All 2012 2011 2010 2009 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (28 results)

  • [Journal Article] Extended field stereotactic radiosurgery for recurrent glioblastoma2012

    • Author(s)
      甲賀智之, 他
    • Journal Title

      Cancer

      Volume: (In Press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integration of corticospinal tractography reduces motor complication after radiosurgery2012

    • Author(s)
      甲賀智之, 他
    • Journal Title

      International Journal of Radiation Oncology, Biology, and Physics

      Volume: 83 Pages: 129133-129133

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcomes of diffusion-tensor tractography integrated stereotactic radiosurgery2012

    • Author(s)
      甲賀智之, 他
    • Journal Title

      International Journal of Radiation Oncology, Biology, and Physics

      Volume: 82 Pages: 799-802

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of technological progress, inter-operator difference and experience of operators in gamma knife radiosurgery for arteriovenous malformation2011

    • Author(s)
      Koga T, Shin M, Maruyama K, Kurita H, Kawamoto S, Saito N.
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 153 Pages: 879-882

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Outcomes of radiosurgery for brain stem arteriovenous malformations.2011

    • Author(s)
      Koga T, Shin M, Terahara A, Saito N.
    • Journal Title

      Neurosurgery

      Volume: 69 Pages: 45-52

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment with high marginal dose is mandatory to achieve long-term control of skull base chordomas and chondrosarcomas by means of stereotactic radiosurgery.2010

    • Author(s)
      Koga T, Shin M, Saito N.
    • Journal Title

      J Neurooncol

      Volume: 98 Pages: 233-238

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcomes of stereotactic radiosurgery for arteriovenous malformations in the thalamus.2010

    • Author(s)
      Koga T, Shin M, Maruyama K, Terahara A, Saito N.
    • Journal Title

      Neurosurgery

      Volume: 67 Pages: 398-403

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of gamma knife radiosurgery in neurosurgery: past and future perspectives.2010

    • Author(s)
      Koga T, Shin M, Saito N.
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 50(9) Pages: 737-749

    • NAID

      10030693096

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Contrast-enhanced magnetic resonance characteristics of arteriovenous malformations after gamma knife radiosurgery: predictors of post-angiographic obliteration.2010

    • Author(s)
      Kunishima K, Shin M, Kunimatsu A, Aoki S, Sasaki H, Koga T, Itoh D, Mori H, Abe O, Ohtomo K, Saito N.
    • Journal Title

      Neurosurgery

      Volume: 67 Pages: 100-109

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment with high marginal dose is mandatory to achieve long-term control of skull base chordomas and chondrosarcomas by means of stereotactic radiosurgery2010

    • Author(s)
      甲賀智之, 他
    • Journal Title

      Journal of Neuro-Oncology

      Volume: (掲載確定)(In Press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The value of image coregistration during stereotactic radiosurgery.2009

    • Author(s)
      Koga T, Maruyama K, Igaki H, Tago M, Saito N.
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 151 Pages: 465-471

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation.2009

    • Author(s)
      Koga T, Morita A, Maruyama K, Tanaka M, Ino Y, Shibahara J, Louis DN, Reifenberger G, Itami J, Hara R, Saito N, Todo T.
    • Journal Title

      Neuro-Oncol

      Volume: 11 Pages: 446-451

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Arcuate fasciculus tractography integrated into gamma knife surgery.2009

    • Author(s)
      Maruyama K, Koga T, Kamada K, Ota T, Itoh D, Ino K, Igaki H, Aoki S Masutani Y, Shin M, Saito N.
    • Journal Title

      J Neurosurg

      Volume: 111 Pages: 520-526

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of arteriovenous malformations with 3-Tesla time-resolved, cibtrast-enhanced, three-dimensional magnetic resonance angiography.2009

    • Author(s)
      Kunishima K, Mori H, Itoh D, Aoki S, Kabasawa H, Koga T, Maruyama K, Masumoto T, Abe O, Ohtomo K.
    • Journal Title

      J Neurosurg

      Volume: 110 Pages: 492-499

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stereotactic radiosurgery for skull base meningioma.2009

    • Author(s)
      Igaki H, Maruyama K, Koga T, Murakami N, Tago M, Terahara A, Shin M, Nakagawa K, Ohtomo K.
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 49 Pages: 456-461

    • NAID

      130000138413

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation2009

    • Author(s)
      甲賀智之, 他
    • Journal Title

      Neuro-Oncology

      Volume: 11 Pages: 446-451

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The value of image coregistration during stereotactic radiosurgery2009

    • Author(s)
      甲賀智之, 他
    • Journal Title

      Acta Neurochirurgica

      Volume: 151 Pages: 465-471

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extended field stereotactic radiosurgery for recurrent glioblastoma

    • Author(s)
      Koga T, Maruyama K, Tanaka M, Ino Y, Saito N, Nakagawa K, Shibahara J, Todo T.
    • Journal Title

      Cancer

      Volume: (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integration of corticospinal tractography reduces motor complication after radiosurgery

    • Author(s)
      Koga T, Shin M, Maruyama K, Kamada K, Ota T, Itoh D, Kunii N, Ino K, Aoki S, Masutani Y, Igaki H, Onoe T, Saito N.
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Outcomes of diffusion-tensor tractography integrated stereotactic radiosurgery

    • Author(s)
      Koga T, Maruyama K, Kamada K, Ota T, Shin M, Itoh D, Kunii N, Ino K, Terahara A, Aoki S, Masutani Y, Saito N.
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delayed complication after gamma knife radiosurgery for mesial temporal lobe epilepsy

    • Author(s)
      Usami K, Kawai K, Koga T, ShinM, Kurita H, Suzuki I, Saito N.
    • Journal Title

      J Neurosurg

      Volume: (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 再発神経膠芽腫の長期腫瘍制御をめざした定位放射線治療の照射や拡大の効果2011

    • Author(s)
      甲賀智之
    • Organizer
      社団法人日本脳神経外科学会総会第70回学術総会
    • Place of Presentation
      パシフィコ横浜(特別シンポジウム)
    • Year and Date
      2011-10-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 再発神経膠芽腫の長期腫瘍制御をめざした定位放射線治療の照射や拡大の効果2011

    • Author(s)
      甲賀智之, 藤堂具紀, 花北俊哉, 辛正廣, 丸山啓介, 武笠晃丈, 齊藤邦昭, 斉藤延人
    • Organizer
      社団法人日本脳神経外科学会総会第70 回学術総会
    • Place of Presentation
      パシフィコ横浜, (特別シンポジウム)
    • Related Report
      2010 Final Research Report
  • [Presentation] Comparison of outcomes after brain radiosurgery with and without use of diffusion-tensor tractography2011

    • Author(s)
      Koga T, Shin M, Hanakita S, Kunii N, Ino K, Masutani Y, Saito N.
    • Organizer
      Tenth biennial congress and exhibition of the international stereotactic radiosurgery society
    • Place of Presentation
      Paris, France
    • Related Report
      2010 Final Research Report
  • [Presentation] 拡散テンソルトラクトグラフィ合成によるガンマナイフ治療の安全性の向上2011

    • Author(s)
      甲賀智之, 丸山啓介, 辛正廣, 鎌田恭輔, 國井尚人, 斉藤延人
    • Organizer
      第34 回日本脳神経CI 学会総会
    • Place of Presentation
      米子コンベンションセンター(鳥取)
    • Related Report
      2010 Final Research Report
  • [Presentation] 脊索腫に対する定位放射線外科治療の役割2010

    • Author(s)
      甲賀智之, 辛正廣, 斉藤延人
    • Organizer
      第28 回日本脳腫瘍学会学術集会
    • Place of Presentation
      軽井沢
    • Year and Date
      2010-11-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 巨大脳動静脈奇形に対する多段階放射線治療の役割2010

    • Author(s)
      甲賀智之, 辛正廣, 丸山啓介, 井垣浩, 斉藤延人
    • Organizer
      第19 回定位放射線治療学会
    • Place of Presentation
      ピアザ淡海(滋賀県)
    • Year and Date
      2010-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Outcomes of stereotactic radiosurgery for intracanalicular vestibular schwannomas.2010

    • Author(s)
      Koga T, Shin M, Saito N.
    • Organizer
      7th Meeting of Asian Society for Neuro-Oncology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-06-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Contribution of technological progress and influence of inter-operator difference in gamma knife radiosurgery for arteriovenous malformation.2010

    • Author(s)
      Koga T, Shin M, Saito N.
    • Organizer
      Leksell Gamma Knife Society 2010 Meeting
    • Place of Presentation
      Nagoya Congress Center
    • Related Report
      2010 Final Research Report
  • [Presentation] Preventing morbidity of gamma knife radiosurgery by integrating tractography.2010

    • Author(s)
      Koga T, Shin M, Maruyama K, Saito N.
    • Organizer
      Asian Leksell Gamma Knife Society 2010 Meeting
    • Place of Presentation
      Nagoya, Japan, (Symposium)
    • Related Report
      2010 Final Research Report
  • [Presentation] さらなる低侵襲化をめざした脳動静脈奇形に対する定位放射線療法, 最新の試み2010

    • Author(s)
      甲賀智之, 辛正廣, 丸山啓介, 金太一, 斉藤延人
    • Organizer
      社団法人日本脳神経外科学会総会第69 回学術総会
    • Place of Presentation
      福岡国際会議場, (シンポジウム)
    • Related Report
      2010 Final Research Report
  • [Presentation] Spetzler-Martin Grading による脳動静脈奇形に対する定位放射線治療と摘出術の治療成績の比較2010

    • Author(s)
      甲賀智之, 辛正廣, 斉藤延人
    • Organizer
      第25 回日本脳神経外科国際学会フォーラム
    • Place of Presentation
      大宮ソニックシティー(埼玉), (教育講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Characteristics of central nervous system germinoma involving the basal ganglia: a literature review.2010

    • Author(s)
      Koga T, Matsutani M.
    • Organizer
      14th International Symposium on Pediatric Neuro-Oncology
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳動静脈奇形に対する定位放射線治療の治療予後を予測するためのグレーディングシステムの提唱2010

    • Author(s)
      甲賀智之, 辛正廣, 寺原敦朗, 斉藤延人
    • Organizer
      第39回日本脳卒中の外科学会
    • Place of Presentation
      岩手県民会館, (シンポジウム)
    • Related Report
      2010 Final Research Report
  • [Presentation] 照射野を拡大した定位放射線外科治療による再発膠芽腫の局所制御2009

    • Author(s)
      甲賀智之
    • Organizer
      第27回日本脳腫瘍学会
    • Place of Presentation
      全日空ゲートタワーホテル(大阪府)
    • Year and Date
      2009-11-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 播種を来したpleomorphic xanthoastrocytomawith anaplastic features に対する定位放射線治療による腫瘍制御2009

    • Author(s)
      甲賀智之, 辛正廣, 丸山啓介, 藤堂具紀, 斉藤延人
    • Organizer
      第18 回日本定位放射線治療学会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2009-07-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 定位放射線治療による脳動静脈奇形のナイダス閉塞後にみられる長期合併症2009

    • Author(s)
      甲賀智之, 辛正廣, 丸山啓介, 寺原敦朗, 斉藤延人
    • Organizer
      第18 回日本定位放射線治療学会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2009-07-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 頭蓋底髄膜腫に対するガンマナイ フの治療成績2009

    • Author(s)
      甲賀智之, 辛 正廣, 斉藤延人
    • Organizer
      第18 回日本定位放射線治療学会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2009-07-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Long-term outcomes of stereotactic radiosurgery for arteriovenous malformations in the thalamus.2009

    • Author(s)
      Koga T, Shin M, Maruyama K, Terahara A, Saito N.
    • Organizer
      First Asia Leksell Gamma Knife Society meeting
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-06-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 高齢者における髄膜腫に対する radiosurgery の治療成績2009

    • Author(s)
      甲賀智之, 辛 正廣, 斉藤延人
    • Organizer
      第22 回日本老年脳経外科学会
    • Place of Presentation
      広島大学, (シンポジウム)
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 照射野を拡大した定位放射線外科治療による再発膠芽腫の局所制御2009

    • Author(s)
      甲賀智之, 藤堂具紀, 稲生靖, 田中実, 武笠晃丈, 寺原敦朗, 斉藤延人
    • Organizer
      第27 回日本脳腫瘍学会
    • Place of Presentation
      全日空ゲートタワーホテル大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Outcomes of stereotactic radiosurgery for skull base meningiomas.2009

    • Author(s)
      Koga T, Shin M, Saito N.
    • Organizer
      2009 joint meeting of the society for neuro-oncology and the AANS/CNS section on tumors
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳動静脈奇形に対する定位的放射線療法の長期治療成績に基づいた治療戦略の展望2009

    • Author(s)
      甲賀智之, 辛正廣, 丸山啓介, 寺原敦朗, 斉藤延人
    • Organizer
      第68 回日本脳神経外科学会総会
    • Place of Presentation
      京王プラザホテル(東京), (シンポジウム)
    • Related Report
      2010 Final Research Report
  • [Presentation] 頭蓋底髄膜腫に対するガンマナイフの治療成績2009

    • Author(s)
      甲賀智之, 辛 正廣, 斉藤延人
    • Organizer
      第21 回日本頭蓋底外科学会
    • Place of Presentation
      アクロス福岡, (シンポジウム)
    • Related Report
      2010 Final Research Report
  • [Presentation] Treatment with high marginal dose is mandatory to achieve long-term control of skull base chordomas and chondrosarcomas by means of stereotactic radiosurgery.2009

    • Author(s)
      Koga T, Shin M, Saito N.
    • Organizer
      Ninth biennial congress and exhibition of the international stereotactic radiosurgery society
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] Long-term outcomes of stereotactic radiosurgery for cerebral arteriovenous malformations of each Spetzler-Martin Grade: Comparison with surgical outcomes.2009

    • Author(s)
      Koga T, Shin M, Maruyama K, Igaki H, Saito N.
    • Organizer
      Ninth biennial congress and exhibition of the international stereotactic radiosurgery society
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] Treatment with high marginal dose is mandatory to achieve long-term control of skull base chordomas and chondrosarcomas by means of stereotactic radiosurgery.2009

    • Author(s)
      Koga T, Shin M, Saito N.
    • Organizer
      The third quadrennial meeting of the world federation of neuro-oncology
    • Place of Presentation
      Pacifico Yokohama
    • Related Report
      2010 Final Research Report
  • [Presentation] Spetzler-Martin grading による脳動静脈奇形に対する定位放射線治療と摘出術の治療成績の比較2009

    • Author(s)
      甲賀智之, 辛 正廣, 斉藤延人
    • Organizer
      第38 回日本脳卒中の外科学会
    • Place of Presentation
      島根県民会館, (シンポジウム)
    • Related Report
      2010 Final Research Report
  • [Presentation] 視床下部過誤腫治療後に残存する難治性非笑い発作の病態と外科治療2009

    • Author(s)
      甲賀智之, 川合謙介, 鎌田恭輔, 太田貴裕, 宇佐美憲一, 斉藤延人
    • Organizer
      第32 回日本てんかん外科学会
    • Place of Presentation
      東京ステーションコンファレンス
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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