Molecular mechanisms associated with 1p 19q loss of heterozygosity in oligodendroglioma
| Project/Area Number |
21791347
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Saitama Medical University (2010)
The University of Tokyo (2009) |
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Principal Investigator |
KOGA Tomoyuki 埼玉医科大学, 医学部, 助教 (40456124)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脳腫瘍 / 乏突起神経膠腫 / 染色体異常 / MYT1L / 神経膠腫 / myelin transcription factor 1-like / 遺伝子発現 / 治療反応性 / 予後 |
|---|
| Research Abstract |
Oligodendrogliomas with 1p19q loss of heterozygosity respond well to chemotherapy compared with those without. However, the molecular mechanisms associated with this chromosomal abnormality are not well known. Based on the results of our previous study, we have targeted a transcriptional factor, myelin transcription factor 1-like (MYT1L). We have performed RT-PCR. Expression level of MYT1L was higher in oligodendrogliomas with 1p19q loss of heterozygosity. These results suggested that the expression of MYT1L is associated with chromosomal change in oligodendrogliomas and possibly useful as diagnostic tool of these tumors.
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Report
(3 results)
Research Products
(49 results)
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[Journal Article] Contrast-enhanced magnetic resonance characteristics of arteriovenous malformations after gamma knife radiosurgery: predictors of post-angiographic obliteration.2010
Author(s)
Kunishima K, Shin M, Kunimatsu A, Aoki S, Sasaki H, Koga T, Itoh D, Mori H, Abe O, Ohtomo K, Saito N.
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Journal Title
Neurosurgery
Volume: 67
Pages: 100-109
Related Report
Peer Reviewed
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[Journal Article] Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation.2009
Author(s)
Koga T, Morita A, Maruyama K, Tanaka M, Ino Y, Shibahara J, Louis DN, Reifenberger G, Itami J, Hara R, Saito N, Todo T.
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Journal Title
Neuro-Oncol
Volume: 11
Pages: 446-451
Related Report
Peer Reviewed
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[Journal Article] Assessment of arteriovenous malformations with 3-Tesla time-resolved, cibtrast-enhanced, three-dimensional magnetic resonance angiography.2009
Author(s)
Kunishima K, Mori H, Itoh D, Aoki S, Kabasawa H, Koga T, Maruyama K, Masumoto T, Abe O, Ohtomo K.
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Journal Title
J Neurosurg
Volume: 110
Pages: 492-499
Related Report
Peer Reviewed
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[Journal Article] Integration of corticospinal tractography reduces motor complication after radiosurgery
Author(s)
Koga T, Shin M, Maruyama K, Kamada K, Ota T, Itoh D, Kunii N, Ino K, Aoki S, Masutani Y, Igaki H, Onoe T, Saito N.
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Outcomes of diffusion-tensor tractography integrated stereotactic radiosurgery
Author(s)
Koga T, Maruyama K, Kamada K, Ota T, Shin M, Itoh D, Kunii N, Ino K, Terahara A, Aoki S, Masutani Y, Saito N.
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: (in press)
Related Report
Peer Reviewed
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