|Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
In the comparison between neural and tumor stem cells, there was some differences such as a weakness of proliferation in the tumor stem cells. We succeeded to culture some cell lines of tumor stem cells from glioma patients. The tumor stem cells could differentiate into neuronal, glial and oligodendreoglial cell lineage which were demonstrated by immunocytochemistry. The circumference of the tumor cells which was non-tumor-stem cells might affect to proliferation of the tumor stem cells. The SIRT 1 gene known as a long life gene was appeared in the CD133 positive cells. The efficacy of the SIRT1 gene in the cells will be examined by retrieving the difference of the amount of the SIRT1 gene expression in the brain tumor stem cell in the future.