• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Co-transplantation of ES Cells and Bone Marrow Stromal Cells for Spinal Cord Injury

Research Project

Project/Area Number 21791375
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNara Medical University

Principal Investigator

MATSUDA Ryosuke  Nara Medical University, 医学部, 助教 (60453164)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脊髄損傷 / 骨髄間質細胞 / ES細胞 / 共培養 / 共移植 / 脊髄間質細胞
Research Abstract

We performed co-transplantation of neural stem cells derived from ES cells and bone marrow stromal cells for spinal cord injury in mice. We checked motor function after spinal cord injury weekly and histopathological examination using neuronal markers. Histopathological examination revealed that neural stem cells derived Es cells differentiated into Nestin positive cells and MAP2 positive cells. There is no significance for motor functional improvement between co-transplantation group and other control groups. The reason for ineffectiveness of this study is unclear. Further study will be required.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report

Research Products

(12 results)

All 2011 2010 2009 Other

All Journal Article Presentation Remarks

  • [Journal Article] Modulated differentiation of embryonic stem cells into hepatocyte-like cells by coculture with hepatic stellate cells.2011

    • Author(s)
      Nishiofuku M, Yoshikawa M, Ouji Y, Saito K, Moriya K, Ishizaka S, Nishimura F, Matsuda R, Yamada S, Fukui H
    • Journal Title

      J Biosci Bioeng 111

      Pages: 71-77

    • NAID

      110008440353

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulated differentiation of embryonic stem cells into hepatocyte-like cells. by coculture with hepatic stellate cells.2011

    • Author(s)
      Nishiofuku M, Matsuda R, et al
    • Journal Title

      J Biosci Bioeng

      Volume: 111 Pages: 71-77

    • NAID

      110008440353

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of murine hepatocytes following collagenase infusion into left ventricle of heart.2010

    • Author(s)
      Ouji Y, Yoshikawa M, Moriya K, Nishiofuku M, Ouji-Sageshima N, Matsuda R, Nishimura F, Ishizaka S
    • Journal Title

      J Biosci Bioeng 110

      Pages: 487-490

    • NAID

      110007880149

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of murine hepatocytes following collagenase infusion into left ventricle of heart.2010

    • Author(s)
      Ouji Y, Matsuda R, et al
    • Journal Title

      J Biosci Bioeng

      Volume: 110 Pages: 487-490

    • NAID

      110007880149

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cotransplantation of mouse embryonic Stem cells and bone marrow stromal cells followingspinal cord injury suppresses2009

    • Author(s)
      Matsuda R, Yoshikawa M, Kimura H, Ouji Y, Nakase H, Nishimura F, Nonaka J, Toriumi H, Yamada S, Nishiofuku M, Moriva K, Ishizaka S, Nakamura M, Sakaki T
    • Journal Title

      Cell transplantation 18

      Pages: 39-54

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of Parkinson's disease model mice with allogeneic embryonic stem cells : necessity of immunosuppressive treatment for sustained improvement.2009

    • Author(s)
      Toriumi H, Yoshikawa M, Matsuda R, Nishimura F, Yamada S, Hirabayashi Nakase H, Nonaka J, Ouji Y, Ishizaka S, Sakaki T.
    • Journal Title

      Neurological Reseach 31

      Pages: 220-227

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Co-transplantation of Mouse Embryonic Stem Cells and Bone Marrow Stromal Cells Following Spinal Cord In jury Suppresses Tumor Development2009

    • Author(s)
      Matsuda R, et al
    • Journal Title

      Cell Transplantation Vol 18

      Pages: 39-54

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of Parkinson's disease model mice with allogeneic embryonic stem cells : necessity of immunosuppressive treatment for sustained improvement.2009

    • Author(s)
      Toriumi H, Matsuda R, et al.
    • Journal Title

      Neurological Reaseach Vol 31(3)

      Pages: 220-227

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Stress Induced Prematured Senescence in Glioblastoma Cell Line and Relationship with Carnitine2010

    • Author(s)
      山田修一, 松田良介, 西村文彦, 朴永銖, 中村光利, 中瀬裕之, 王寺幸輝, 吉川正英, 石坂重明
    • Organizer
      日本脳腫瘍学会
    • Place of Presentation
      軽井沢
    • Year and Date
      2010-11-28
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Stress Induced Prematured Senescence in Glioblastoma Cell Line and Relationship with Carnitine2010

    • Author(s)
      山田修一, 松田良介, 西村文彦, 朴永銖, 中村光利, 中瀬裕之, 王寺幸輝, 吉川正英, 石坂重明
    • Organizer
      日本分子脳神経外科学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 脊髄損傷に対するES細胞移植治療の問題点2009

    • Author(s)
      松田良介, 山田修一, 中瀬裕之, 王寺幸輝, 吉川正英, 石坂重明
    • Organizer
      日本分子脳神経外科学会
    • Place of Presentation
      岡山
    • Year and Date
      2009-09-20
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-03-31   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi