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Identification of novel growth factor for Glioma cancer stem cells

Research Project

Project/Area Number 21791377
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKeio University

Principal Investigator

TAKAHASHI Satoshi  Keio University, 医学部, 研究員 (20383870)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脳腫瘍学 / 腫瘍幹細胞 / 脳腫瘍 / 幹細胞 / 増殖因子 / 神経膠腫 / 脳腫瘍幹細胞
Research Abstract

We have conducted our research for the purpose of identifying novel growth factors for glioma cancer stem cells, and identified KIF23 and uPARAP. Downregulation of KIF23 in glioma cells suppressed their proliferation. Downregulation of uPARAP in glioma cells suppressed migration and invasion properties of glioma cells through changes in actin cytoskeleton. We have also confirmed the expressions of the both molecules in glioma cancer stem cells at protein level.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells.2011

    • Author(s)
      Takahashi S, Yamada-Okabe H, Hamada K, et al.
    • Journal Title

      J Neurooncol. 103(2)

      Pages: 267-276

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells.2010

    • Author(s)
      Takahashi S, Yamada-Okabe H, Hamada K, Ohta S, Kawase T, Yoshida K, Toda M
    • Journal Title

      J Neurooncol

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脳腫瘍幹細胞・グリオーマ共通抗原の発現および機能解析2010

    • Author(s)
      戸田正博、田伏将尚、大多茂樹、深谷雷太、高橋里史、吉田一成
    • Organizer
      第28回日本脳腫瘍学会学術集会
    • Place of Presentation
      軽井沢
    • Year and Date
      2010-11-29
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] GliomaにおけるKIF23発現の検討と機能解析2010

    • Author(s)
      高橋里史, 戸田正博, 吉田一成
    • Organizer
      第69回社団法人日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] GliomaにおけるKIF23発現の検討と機能解析2010

    • Author(s)
      高橋里史、戸田正博、吉田一成
    • Organizer
      日本脳神経外科学会第69回学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] RNA interference-mediated down-regulation of uPARAP decreases invasion and migration property in glioma cells through reorganization of the actin cytoskeleton.2010

    • Author(s)
      Takahashi S, Toda M, Yamada-Okabe H, Hamada K, Kawase T, Yoshida K
    • Organizer
      慶應ニューロサイエンス研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-29
    • Related Report
      2010 Final Research Report
  • [Presentation] RNA interference-mediated down-regulation of uPARAP decreases invasion and migration property in glioma cells through reorganization of the actin cytoskeleton.2010

    • Author(s)
      Takahashi S, Toda M, Yamada-Okabe H, Hamada K, Kawase T, Yoshida K
    • Organizer
      慶應ニューロサイエンス
    • Place of Presentation
      東京
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] RNA interference-mediated downregulation of uPARAP decreases invasion and migration property in glioma cells through reorganization of the actin cytoskeleton2010

    • Author(s)
      Satoshi Takahashi, Masahiro Toda, Hikaru Sasaki, Takeshi Kawase.
    • Organizer
      AACR 101^<st> annual meeting 2010
    • Place of Presentation
      Washington, D.C.
    • Year and Date
      2010-04-18
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] siRNAを用いたuPARAP knock downはGlioma培養細胞の移動・浸潤能を抑制する2010

    • Author(s)
      高橋里史, 河瀬斌, 戸田正博
    • Organizer
      第5回「脳腫瘍の基礎シンポジウム」
    • Place of Presentation
      東京
    • Year and Date
      2010-01-30
    • Related Report
      2010 Final Research Report
  • [Presentation] P.002 Down-regulation of membrane protein uPARAP makes glioma cells immobile and can be a target for novel glioma therapy2010

    • Author(s)
      S.Takahashi, T.Kawase, M.Toda
    • Organizer
      9^<th> congress of the European association of neurooncology
    • Place of Presentation
      Maastricht, Netherland
    • Related Report
      2010 Final Research Report
  • [Presentation] Down-regulation of membrane protein uPARAP makes glioma cells immobile and can be a target for novel glioma therapy2010

    • Author(s)
      Takahashi S, Kawase T, Toda M
    • Organizer
      9^<th> congress of the European association of neurooncology
    • Place of Presentation
      Maastricht
    • Related Report
      2010 Annual Research Report
  • [Presentation] GliomaにおけるuPARAP発現の検討と機能解析2009

    • Author(s)
      高橋里史, 戸田正博, 河瀬斌
    • Organizer
      第68回社団法人日本脳神経外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-16
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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