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Organization of genetics, the new grade for the pediatric brain tumor

Research Project

Project/Area Number 21791379
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionTokyo Women's Medical University

Principal Investigator

AIHARA Yasuo  Tokyo Women's Medical University, 医学部, 助教 (50287372)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords悪性脳腫瘍 / 小児 / 予後 / 悪性度分類 / 遺伝子検査 / 化学療法 / 放射線療法 / 播種 / 脳腫瘍 / 遺伝子
Research Abstract

We analyzed the oncocyte (27 cases in total) which we delivered from 8 onset medulloblastoma dissemination cases, glioma 5 case, ependymoma 14 case this time.The gene expression levels were different in each malignant tumor. SUFU, ERBB2, PCNA developed the disseminated meningioma as compared with a on-disseminated medulloblastoma high. The results were similar for the onset clinical manifestations.It developed high, and PDGFRa and G-CSFR resembled a gliomatous gene expression pattern in the gene expression pattern of the ependymoma in all gliomas case and showed the tendency that was different from the expression patterns of the medulloblastoma.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (2 results)

  • [Journal Article] High-dose chemotherapy followed by autologous and allogeneic peripheral blood stem cell transplantation for recurrent disseminated trilateral retinoblastoma.2011

    • Author(s)
      Tsuruta T, Aihara Y, Kanno H, Kiyotani C, Maebayashi K, Sakauchi M, Osawa M, Fujii H, Kubo O, Okada Y.
    • Journal Title

      Childs Nery Syst. 27(6)

      Pages: 1019-24

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Shared molecular targets in pediatric gliomas and ependymomas.2011

    • Author(s)
      Tsuruta T, Aihara Y, Kanno H, Funase M, Murayama T, Osawa M, Fujii H, Kubo O, Okada Y.
    • Journal Title

      Pediatr Blood Cancer. doi:10.1002/pbc.23009.(Epub ahead of print)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Shared molecular targets in pediatric gliomas and ependymomas.2011

    • Author(s)
      Yasuo Aihara
    • Journal Title

      Pediatr Blood Cancer.

      Volume: Feb 4 10 Pages: 1-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-dose chemotherapy followed by autologous and allogeneic peripheral blood stem cell transplantation for recurrent disseminated trilateral retinoblastoma.2011

    • Author(s)
      Yasuo Aihara
    • Journal Title

      Childs Nerv Syst

      Volume: Mar 19(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel method for controlling cerebrospinal fluid flow and intracranial pressure by use of a tandem shunt valve system.2010

    • Author(s)
      Aihara Y, Kawamata T, Mitsuyama T, Hori T, Okada Y.
    • Journal Title

      Pediatr Neurosurg. 46(1)

      Pages: 12-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical standard of neurosurgical disorder (15) parasellar tumor including craniopharyngioma2010

    • Author(s)
      Kawamata T, Hori T, Amano K, Aihara Y, Kubo O, Okada Y.
    • Journal Title

      No Shinkei Geka.(Review. Japanese. No abstract available.) 38(2)

      Pages: 185-93

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Double high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation for primary disseminated meddul loblastoma : a report of 3 cases.2010

    • Author(s)
      Aihara Y
    • Journal Title

      J Pediatr Hematol Oncol Mar;32(2)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 積極的摘出術を目指した小児神経膠腫67例の治療成績と今後の展望2010

    • Author(s)
      藍原康雄
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児脳室内絨毛癌に対する集学的治療戦略2009

    • Author(s)
      藍原康雄
    • Organizer
      第14回日本脳腫瘍の外科学会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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