The control of neural-glial spinal cells microenvironment after traumatic injury through transfection of neurotrophic factor
| Project/Area Number |
21791389
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Fukui |
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Principal Investigator |
NAKAJIMA Hideaki University of Fukui, 医学部, 助教 (10397276)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脊髄損傷 / 神経栄養因子 / 逆行性導入 / 遺伝子治療 / アデノウィルスベクター / アポトーシス / 神経保護 / 軸索再生 / 遺伝子導入 / apoptosis抑制 / 神経保護効果 / 神経再生 |
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| Research Abstract |
It is very important to deliver the neurotrophins with safety and effectively. Our results suggest that targeted retrograde AdV-BDNF-gene in vivo delivery may enhance neuronal and oligodendroglial survival sustained mechanical compression spinal cord injury. The suppression of apoptosis may one of the mechanism of these positive results. The method is a potentially suitable approach for the delivery of therapeutic genes important to promote the survival of neurons and oligodendroglia after traumatic spinal cord injury.
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Report
(3 results)
Research Products
(25 results)
