The role of SIRT1 in chondrocytes
| Project/Area Number |
21791393
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
MATSUSHITA Takehiko Kobe University, 医学部附属病院, 特命助教 (40467650)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 関節病学 / SIRT1 / 軟骨 / 変形性関節症 / SIET1 / 軟骨細胞 |
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| Research Abstract |
In this study, we found that the overexpression of SRIT1 counteracted against the IL-1β- induced expression of cartilage degrading enzymes, which presumably play important roles in cartilage degradation. Our study suggested that SIRT1 can play protective roles in chondrocytes.
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Report
(3 results)
Research Products
(11 results)
