The function of glia limitans in spinal cord injury
| Project/Area Number |
21791398
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
YONEZAWA Tomoko Okayama University, 大学院・医歯薬学総合研究科, 助教 (30304299)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脊椎脊髄病学 / 脊髄損傷 / アストログリア |
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| Research Abstract |
Astroglia form a glia limitans around the injured tissue after spinal cord injury. We used a mouse spinal cord injury model and found that the glia limitans was associated with the suppression of infiltration of inflammatory cells and the perivascular space provides a conduit for inflammatory cells to the expansion from the injury core. In addition, we found that type IV collagen induced expression of thrombospondin-1 in astrocytes. Our results suggest that glia limitans play an important role in the repair process following injured central nervous tissue.
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Report
(3 results)
Research Products
(8 results)
