Enhanced effects of a carbon nanofiber with recombinant human BMP-2 in Rats Spinal Fusion Model
| Project/Area Number |
21791405
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | カーボンナノファイバー / 骨誘導能 / ラット脊椎固定モデル / ラット大腿骨骨折モデル / BMP / マイクロCT / Bisphosphonate |
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| Research Abstract |
We aimed to investigate the enhanced effect of a carbon nanofiber and recombinant human BMP-2 in a rat spinal fusion model and rat femoral fracture model. The synergic effect of a carbon nanofiber and recombinant human BMP-2 was efficacious for fracture repair and spinal fusion significantly enhanced bone fusion. Our results suggest that this combination facilitates bone healing and has potential clinical application.
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Report
(4 results)
Research Products
(3 results)
