Enhanced effects of a carbon nanofiber with recombinant human BMP-2 in Rats Spinal Fusion Model

• Project/Area Number: 21791405
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Oita University
• Principal Investigator: MIYAZAKI Masashi 大分大学, 医学部, 助教 (30527742)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: カーボンナノファイバー / 骨誘導能 / ラット脊椎固定モデル / ラット大腿骨骨折モデル / BMP / マイクロCT / Bisphosphonate

Research Abstract

We aimed to investigate the enhanced effect of a carbon nanofiber and recombinant human BMP-2 in a rat spinal fusion model and rat femoral fracture model. The synergic effect of a carbon nanofiber and recombinant human BMP-2 was efficacious for fracture repair and spinal fusion significantly enhanced bone fusion. Our results suggest that this combination facilitates bone healing and has potential clinical application.

Research Products

• [Journal Article] Manipulation of the anabolic and catabolic responses with BMP-2 and zoledronic acid in a rat femoral fracture model (2011)
  • Author(s): Doi Y, Miyazaki M, Yoshiiwa T, Hara K, Kataoka M, Tsumura H
  • Journal Title: Bone Volume: 49 Pages: 777-782
• [Journal Article] Manipulation of the anabolic and catabolic responses with BMP-2 and zoledronic acid in a rat (2011)
  • Author(s): Doi Y, Miyazaki M, Yoshiiwa T, Hara K, Kataoka M, Tsumura H
  • Journal Title: Bone Volume: 49 Pages: 777-782
  • Peer Reviewed
• [Remarks]
  • URL: http://www.med.oita-u.ac.jp/index.html