Homing of osteogenic progenitors to site of new bone formation in artificial bone substitute

• Project/Area Number: 21791406
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Yokohama City University
• Principal Investigator: KUMAGAI Ken Yokohama City University, 医学部, 助教 (10468176)
• Research Collaborator: MUSCHLER George F Orthopaedic Research Center, Cleveland Clinic, Director
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 人工骨 / 骨形成 / 末梢血由来細胞 / ホーミング / 骨前駆細胞 / 骨再生

Research Abstract

This study demonstrated that bone formation was stimulated by the addition of bone marrow cells to subcutaneously implanted porous β-TCP blocks in mouse. The data also suggested that recipient derived osteogenic cells migrate into the ceramic pores and contribute to new bone formation. A possible source of osteogenic cells is cells adjacent to local site or circulating osteogenic cells.

Research Products

• [Journal Article] 最新学際情報 骨折治癒におけるcirculating osteogenic cellの関与 (2010)
  • Author(s): 熊谷研, 齋藤知行
  • Journal Title: 関節外科 29(6) Pages: 749-751
• [Journal Article] The design and use of animal models for translational research in bone tissue engineering and regenerative medicine. (2010)
  • Author(s): Muschler GF, Raut VP, Patterson TE, Wenke JC, Hollinger JO.
  • Journal Title: Tissue Eng Part B Rev. 16(1) Pages: 123-145
• [Journal Article] Opening wedge high tibial osteotomy affects both the lateral patellar tilt and patellar height. (2010)
  • Author(s): Bito H, Takeuchi R, Kumagai K, Aratake M, Saito I, Hayashi R, Sasaki Y, Saito T.
  • Journal Title: Knee Surg Sports Traumatol Arthrosc. 18(7) Pages: 955-960
• [Journal Article] 骨折治癒におけるcirculating osteogenic cellの関与 (2010)
  • Author(s): 熊谷研, 齋藤知行
  • Journal Title: 関節外科 Volume: 29 Pages: 749-751
• [Presentation] Bone formation and homing of circulating connective tissue progenitors at fracture site were enhanced by low-intensity pulsed ultrasound. (2010)
  • Author(s): Kumagai K, Takeuchi R, Ishikawa H, Yamaguchi Y, Fujisawa T, Kuniya T, Takagawa S, Saito T.
  • Organizer: 7th Combined Meeting of the Orthopaedic Research Societies
  • Place of Presentation: Kyoto
• [Presentation] Recruitment of recipient derived osteogenic connective tissue progenitors to β-tricalcium phosphate scaffold combined with bone marrow cells. (2010)
  • Author(s): Kumagai K, Takeuchi R, Ishikawa H, Saito I, Yamaguchi Y, Chiba N, Takagawa S, Saito T.
  • Organizer: 56th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: New Orleans
• [Presentation] Bone formation and homing of circulating connective tissue progenitors at fracture site were enhanced by low-intensity pulsed ultrasound. (2010)
  • Author(s): 熊谷研
  • Organizer: 7th Combined Meeting of the Orthopaedic Research Societies
  • Place of Presentation: 京都 京都国際会館
• [Presentation] Recruitment of recipient derived osteogenic connective tissue progenitors to β- tricalcium phosphate scaffold combined with bone marrow cells. (2010)
  • Author(s): 熊谷研
  • Organizer: 56th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] 骨膜除去骨折モデルへの低出力超音波刺激による骨形成促進と末梢血由来骨前駆細胞の関与 (2009)
  • Author(s): 熊谷研, 竹内良平, 荒武正人, 斎藤泉, 尾藤晴彦, 林陸, 佐々木洋平, 齋藤知行
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜
• [Presentation] Effects of Low-Intensity Pulsed Ultrasound on Intramedullary Bone Formation and Homing of Circulating Connective Tissue Progenitors in Fracture with Periosteal Stripping. (2009)
  • Author(s): Kumagai K, Takeuchi R, Ishikawa H, Saito I, Yamaguchi Y, Chiba N, Takagawa S, Saito T.
  • Organizer: 31st Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Denver, CO
• [Presentation] Low-intensity pulsed ultrasound stimulates iIntramedullary bone formation and homing of circulating connective tissue progenitors at fracture site with periosteal stripping in mice. (2009)
  • Author(s): Kumagai K, Takeuchi R, Aratake M, Saito I, Bito H, Sasaki Y, Saito T.
  • Organizer: 55th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Las Vegas, NV
• [Book] 内側型変形性膝関節症に対する高位脛骨骨切り術-内側楔状開大型骨切り術-.OS Now Instruction 16膝・足関節および足趾の骨切り術 (2010)
  • Author(s): 熊谷研, 齋藤知行
  • Publisher: メジカルビュー社