|Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
We showed that histone deacetylase inhibitor SAHA induced apoptosis against parental drug-sensitive Ewing's sarcoma cells, however induced autophagic cell death against multidrug-resistant cells which was resistant to the apoptosic signals. Furthermore, we showed that SARA exhibited the antitumor effect against the animal model of multidrug-resistant Ewing's sarcoma.