The development and analyses of the mouse model of age-related osteoporosis.

• Project/Area Number: 21791416
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Juntendo University
• Principal Investigator: SAITA Yoshitomo 順天堂大学, 医学部, 助教 (00534885)
• Co-Investigator(Kenkyū-buntansha): NOJIRI Hidetoshi 順天堂大学, 医学部, 助教 (10317456)
• Co-Investigator(Renkei-kenkyūsha): SHIMIZU Takahiko 千葉大学, 大学院・医学研究科, 准教授 (40301791)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 老化 / 骨粗鬆症 / 酸化ストレス / スーパーオキサイドディスムターゼ(SOD) / 遺伝子 / モデルマウス / CuZn-SOD / 活性酸素

Research Abstract

We revealed that the relationships between oxidative stress and age-related osteoporosis by analyzing the bone tissue of superoxide dismutase 1(SOD1). deficient mouse. This mouse showed low turnover bone remodeling osteoporosis similar to that of age-related osteoporosis and that was rescued by oral administration of vitamin C. These results may help us to know the unknown mechanisms and establishment of the treatment strategy for age-related osteoporosis.

Research Products

• [Journal Article] Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking (2011)
  • Author(s): Nojiri, Saita, et al
  • Journal Title: Journal of Bone and Mineral Research Volume: Volume 26 Pages: 2682-2694
  • NAID: 40019538687
  • Peer Reviewed
• [Journal Article] Cytoplasmic superoxide causes bone fragility owing to low-tumover osteoporosis and impaired collagen cross-linking (2011)
  • Author(s): Nojiri, Saita, et al
  • Journal Title: Journal of Bone and Mineral Research, pages 2682-2694, November 2011 Volume: Volume 26,Issue 11 Pages: 2682-2694
  • Peer Reviewed
• [Presentation] Vitamin C Administration Markedly Ameliorates Bone Loss by Restoring the Osteoblastic Viability in Sod1-Deficient Mice (2011)
  • Author(s): Hidetoshi Nojiri
  • Organizer: 第33回アメリカ骨代謝学会
  • Place of Presentation: アメリカ・サンディエゴ
  • Year and Date: 2011-09-18
• [Presentation] Mitochondrial Superoxide Dismutase Regulates Proliferation and Differentiation of Osteoblasts (2011)
  • Author(s): Keiji Kobayashi
  • Organizer: 第33回アメリカ骨代謝学会
  • Place of Presentation: アメリカ・サンディエゴ
  • Year and Date: 2011-09-17
• [Presentation] The Role of Oxidative Stress and Antioxidant Enzymes in Bone Under Mechanical Unloading (2011)
  • Author(s): Daichi Morikawa
  • Organizer: 第33回アメリカ骨代謝学会
  • Place of Presentation: アメリカ・サンディエゴ
  • Year and Date: 2011-09-16
• [Presentation] スーパーオキサイドディスムターゼ1(SOD1)欠損は低代謝回転型骨量減少と加齢性コラーゲン架橋変化を引き起こし骨脆弱化する (2011)
  • Author(s): 野尻英俊
  • Organizer: 日本骨代謝学会学術集会
  • Place of Presentation: 新大阪
• [Presentation] メカニカルストレス応答における酸化ストレスと抗酸化酵素の解析 (2011)
  • Author(s): 森川大智
  • Organizer: 日本骨代謝学会学術集会
  • Place of Presentation: 新大阪
• [Presentation] スーパーオキサイドディスムターゼ1(SOD1)による骨代謝制御機構の解析 (2011)
  • Author(s): 斎田良知
  • Organizer: 日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋
• [Presentation] 廃用性骨萎縮における活性酸素産生と抗酸化酵素SOD1の役割(会議録) (2011)
  • Author(s): 森川大智
  • Organizer: 日本骨整形外科学会基礎学術集会
  • Place of Presentation: 前橋
• [Presentation] 廃用性骨萎縮における活性酸素産生と抗酸化酵素SOD1の役割 (2011)
  • Author(s): 森川大智
  • Organizer: 日本骨整形外科学会基礎学術集会
  • Place of Presentation: 前橋(会議録)
• [Presentation] Intracellular Superoxide Dismutase Deficiency Decreased Bone Mass In Vivo by Impairment of Cell Viability and Redox Balance in Osteoblasts. (2010)
  • Author(s): 斎田良知
  • Organizer: 第32回アメリカ骨代謝学会
  • Place of Presentation: Toronto, Ontario, Canada
  • Year and Date: 2010-10-17
• [Presentation] Superoxide Dismutase Deficiency in Cytoplasm Exacerbated Bone Loss Under Reduced Mechanical Loading. (2010)
  • Author(s): 森川大智
  • Organizer: 第32回アメリカ骨代謝学会
  • Place of Presentation: Toronto, Ontario, Canada
  • Year and Date: 2010-10-16
• [Presentation] Meet the Expert 1講演名:酸化ストレスと骨代謝-SOD欠損マウスを用いた解析- (2010)
  • Author(s): 清水孝彦
  • Organizer: 第28回日本骨代謝学会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-21
• [Presentation] MOUSE LACKING IN INTRACELLULAR SUPEROXIDE DISMUTASE INCREASED REACTIVE OXYGEN SPECIES IN OSTEOBLASTS AND SUPPRESSED OSTEOBLASTIC ABILITY LEADING TO OSTEOPOROTIC PHENOTYPES IN BONE. (2010)
  • Author(s): 斎田良知
  • Organizer: 国際骨粗鬆症学会
  • Place of Presentation: Firenze, Italy
• [Presentation] INTRACELLULAR SUPEROXIDE DISMUTASE DEFICIENCY WAS NOT ENHANCED OVARIECTOMYINDUCED BONE LOSS (2010)
  • Author(s): 森川大智
  • Organizer: 国際骨粗鬆症学会
  • Place of Presentation: Firenze, Italy
• [Presentation] Mice deficient in CuZn-superoxide dismutase exhibit low bone mass and delayed fracture healing. (2009)
  • Author(s): 斎田良知
  • Organizer: 第31回アメリカ骨代謝学会
  • Place of Presentation: アメリカ・デンバー
  • Year and Date: 2009-09-11
• [Presentation] Copper/zinc superoxide dismutase deficiency causes low turnover osteopenia via osteoblastic dysfunction (2009)
  • Author(s): 野尻英俊
  • Organizer: 第31回アメリカ骨代謝学会
  • Place of Presentation: アメリカ・デンバー
  • Year and Date: 2009-09-11
• [Remarks]
  • URL: http://www.tmig.or.jp/J_TMIG/j_research/DA12.html
• [Remarks]
  • URL: http://www.tmig.or.jp/J_TMIG/j_research/DA12.html