The development and analyses of the mouse model of age-related osteoporosis.
| Project/Area Number |
21791416
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NOJIRI Hidetoshi 順天堂大学, 医学部, 助教 (10317456)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Takahiko 千葉大学, 大学院・医学研究科, 准教授 (40301791)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 老化 / 骨粗鬆症 / 酸化ストレス / スーパーオキサイドディスムターゼ(SOD) / 遺伝子 / モデルマウス / CuZn-SOD / 活性酸素 |
|---|
| Research Abstract |
We revealed that the relationships between oxidative stress and age-related osteoporosis by analyzing the bone tissue of superoxide dismutase 1(SOD1). deficient mouse. This mouse showed low turnover bone remodeling osteoporosis similar to that of age-related osteoporosis and that was rescued by oral administration of vitamin C. These results may help us to know the unknown mechanisms and establishment of the treatment strategy for age-related osteoporosis.
|
Report
(4 results)
Research Products
(19 results)
