Role of Wnt/β-catenin signaling on cartilage matrix degradation
Project/Area Number |
21791417
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
|
Research Institution | Juntendo University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 軟骨基質分解 / 変形性関節症 / Wnt/β-カテニンシグナル / 軟骨基質変性 / Wnt / β-カテニンシグナル |
Research Abstract |
We created a new transgenic mouse model in which Wnt/β-catenin signaling can be activated in cartilage for specific periods of time. Our data provide evidence that Wnt/β-catenin signaling has important and distinct roles in growth plate and articular cartilage and that postnatal dysregulation of this signaling pathway causes diverse structural and functional changes in the two cartilaginous structures.
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Report
(4 results)
Research Products
(10 results)