|Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Perlecan (Perl) is a heparin sulfate proteoglycan required for cartilage development. This study investigated the role of Perl for vascular invasion in growth plate development.While the vascular invasion was inhibited, VEGF expression was increased in Perl-/- growth plate. In organ culture experiment, the growth plate was expanded by the addition of FGF-FGFR inhibitor even though the absence of Perl.
These data indicate that Perl is essential for vascular invasion in growth plate development by not only modulating FGF signaling but also regulating VEGF function.