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Effects of LECT2 on chondrocyte differentiation

Research Project

Project/Area Number 21791422
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionResearch Institute, International Medical Center of Japan (2010-2011)
Nihon University (2009)

Principal Investigator

OKUMURA Akinori  独立行政法人国立国際医療研究センター, 臓器障害研究部, 上級研究員 (90392357)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords骨・軟骨代謝学 / LECT2 / 成長板軟骨 / 蛋白質 / 発生・分化
Research Abstract

Regulatory mechanisms of chondrocyte differentiation in the growth plate are still not fully understood. In this study, we analyzed effects of LECT2 on growth plate chondrocyte differentiation using Lect2-deficient mice and a prechondrocytic cell line. Histological analysis revealed that Lect2-KO mice have slightly abnormal growth plate structure. DNA microarray analysis shows that addition of LECT2 leads to changes in factors of chondrocyte differentiation in prechondrocytic cell line. These results suggest that LECT2 might participate in the differentiation of growth plate chondrocyte.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Identification and assignment of three disulfide bonds in mammalian leukocyte cell-derived chemotaxin 2 by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry2009

    • Author(s)
      Akinori Okumura, Takehiro Suzuki, Naoshi Dohmae, Tomoya Okabe, Yuki Hashimoto, Katsuyoshi Nakazato, Hideaki Ohno, Yoshitsugu Miyazaki, Satoshi Yamagoe
    • Journal Title

      BioScience Trends

      Volume: 3 Pages: 139-143

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and assignment of three disulfide bonds in mammalian leukocyte cell-derived chemotaxin 2 by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry2009

    • Author(s)
      奥村彰規
    • Journal Title

      BioScience Trends 3巻

      Pages: 139-143

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ガラクトサミン/LPS肝障害モデルを用いたLECT2の機能解析2009

    • Author(s)
      奥村彰規、大川原明子、山越智
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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