Initiating mechanism of bone remodeling influenced by the integrity of osteocytic cellular network
| Project/Area Number |
21791423
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
KURATA Kosaku Kyushu University, 大学院・工学研究院, 准教授 (00368870)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 骨細胞 / ネットワーク / 疲労亀裂 / 骨リモデリング / 細胞・組織 |
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| Research Abstract |
The aim of this study was to investigate the mechanism of bone remodeling while focusing on the integrity of osteocyte network. Both an in vitro experimental system that could apply local mechanical damage to the cultured osteocytes and an animal model that could give a fatigue microcrack to a mouse tibia were developed. A large deformation of the culture substrate or bone matrix damaged the osteocyte network, and apoptotic cells were derived around the necrotic osteocytes. This apoptotic cell induction would be a key response for initiating bone remodeling, by which a damaged bone matrix could be repaired locally and appositional bone formation would be occurred to compensate the drop of bone strength.
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Report
(3 results)
Research Products
(17 results)
