The neuroprotective effects of a combination of post-ischemic dexmedetomidine and hypothermia after transient forebrain ischemia in rats

• Project/Area Number: 21791430
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Akita University
• Principal Investigator: SATO Koji Akita University, 医学部, 助教 (80333938)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 一過性前脳虚血 / デクスメデトミジン / 虚血後投与 / 低体温 / 短期予後 / 長期予後

Research Abstract

The combination of post-ischemic dexmedetomidine and hypothermia provided comparable short-term neuroprotection with either of the two therapies alone after transient forebrain ischemia in rats. The combination of pre-ischemic dexmedetomidine and hypothermia improved long-term histological outcome of hippocampal CA1 neurons compared with either of two therapies alone.

Research Products

• [Journal Article] Neuroprotective effects of combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats. (2010)
  • Author(s): Koji Sato, Tetsu Kimura, Toshiaki Nishikawa, Yoshitsugu Tobe, Yoko Masaki.
  • Journal Title: Acta Nnaesthesiologica Scandinavica Vol 54 Pages: 377-382
  • Peer Reviewed
• [Journal Article] Neuroprotective effects of combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats (2010)
  • Author(s): Koji Sato, Tetsu Kimura, Toshiaki Nishikawa, Yoshitsugu Tobe, Yoko Masaki
  • Journal Title: Acta Anaesthesiologica Scandinavica Vol.54 Pages: 377-382
  • Peer Reviewed
• [Presentation] 成人における右内頚静脈からの中心静脈カテーテル挿入長についての検討 (2010)
  • Author(s): 佐藤浩司、工藤良平、中島麻衣子、梅原志乃、西川俊昭
  • Organizer: 日本臨床麻酔学会第30回大会
  • Place of Presentation: アスティとくしま(徳島)
  • Year and Date: 2010-11-04
• [Presentation] ラットー過性前脳虚血モデルにおけるデクスメデトミジン虚血後投与と低体温併用療法の脳保護効果 (2010)
  • Author(s): 佐藤浩司、木村哲、西川俊昭
  • Organizer: 日本麻酔科学会第57回大会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2010-06-03
• [Presentation] ラット一過性前脳虚血モデルにおけるデクスメデトミジン虚血後投与と低体温併用療法の脳保護効果 (2010)
  • Author(s): 佐藤浩司、木村哲、西川俊昭
  • Organizer: 日本麻酔科学会第57回大会
  • Place of Presentation: マリンメッセ福岡(福岡県)
  • Year and Date: 2010-06-03
• [Remarks] ホームページ等