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Development of neuropathic pain cure using a nerve regeneration and a neurodifferentiate factor

Research Project

Project/Area Number 21791432
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionGunma University

Principal Investigator

SEKIMOTO Kenichi  群馬大学, 医学部, 助教 (90515090)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経障害性疼痛 / Notch signal / Notchシグナル
Research Abstract

In cultures with or without EGF (epidermal growth factor) which are main growth factors with a neural stem/progenitor cells in the postnatal cerebellum, Notch 1 and Jagged 1 express into these cells. When Notch signaling activated in these cells by overexpression of Notch intracellular domein (NICD), in HERP1, and 2 and HES1, the difference was not observed in the amount of revelation of the target gene. But Activation of Notch signaling increased HES5 in these cells.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2011 2009

All Presentation (3 results) Book (4 results)

  • [Presentation] 当病院麻酔科蘇生科外来におけるガバペンチン使用症例の検討2009

    • Author(s)
      関本研一, 他
    • Organizer
      日本ペインクリニック学会第43回学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-07-18
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 当院緩和ケアチーム介入症例におけるガバペンチン使用症例の検討2009

    • Author(s)
      関本研一, 他
    • Organizer
      第14回日本緩和医療学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-06-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 当病院緩和ケアチーム介入症例におけるガバペンチン使用症例の検討2009

    • Author(s)
      関本研一
    • Organizer
      第14回日本緩和医療学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-06-19
    • Related Report
      2009 Annual Research Report
  • [Book] 真興交易(株),CTガイド下神経ブロック2011

    • Author(s)
      関本研一
    • Publisher
      医書出版部
    • Related Report
      2011 Final Research Report
  • [Book] CTガイド下神経ブロック2011

    • Author(s)
      齋藤繁
    • Publisher
      真興交易(株)
    • Related Report
      2010 Annual Research Report
  • [Book] 透視下神経ブロック法(Gasser神経節ブロック)2009

    • Author(s)
      関本研一
    • Publisher
      医学書院
    • Related Report
      2011 Final Research Report
  • [Book] 透視下神経ブロック法(Gasser 神経節ブロック)2009

    • Author(s)
      関本研一(分担執筆)大瀬戸清茂編
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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