Effects of general anesthetics on glucose metabolism in fed rats with hemorrhagic shock and ischemia/reperfusion

Research Project

Project/Area Number	21791437
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Anesthesiology/Resuscitation studies
Research Institution	The University of Tokyo
Principal Investigator	KITAMURA Takayuki 東京大学, 医学部附属病院, 助教 (50302609)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	糖代謝 / 全身麻酔 / 嫌気的代謝 / 出血性ショック / 虚血再灌流
Research Abstract	When compared to sevoflurane anesthesia, propofol anesthesia enhances insulin secretion under aerobic as well as anaerobic conditions. It is probable that adenosine triphosphate-sensitive potassium channels in beta-islet cells are involved in the different effects of sevoflurane anesthesia and propofol anesthesia on insulin secretion. Changes in both insulin secretion and insulin sensitivity during ischemia/reperfusion under propofol anesthesia are markedly different from those under sevoflurane anesthesia. During ischemia/reperfusion under propofol anesthesia, changes in insulin sensitivity seemed to be correlated with changes in plasma tumor necrosis factor-alpha levels.