Effects of GABAB receptors on Immune System in Airway Epithelium

• Project/Area Number: 21791444
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Gifu University
• Principal Investigator: SUGIYAMA Yoko Gifu University, 医学系研究科, 助教 (70444255)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 気道 / 免疫 / シグナル伝達 / サイトカイン / ムチン / 麻酔薬 / GABA受容体 / IL-8 / シグナル伝逹

Research Abstract

Propofol enhanced TNF α induced-IL8 production via GABAA receptors in human airway epithelial cells. GABAB receptor agonists had no effect on IL-8 production. Midazolam inhibited TGF α induced-MUC5AC production in a GABAA receptor independent manner. These results suggest that GABAA receptors may become a new therapeutic target of airway inflammation.

Research Products

• [Presentation] 気道上皮細胞のサイトカイン産生におけるプロポフォールの作用 (2010)
  • Author(s): 杉山陽子、田辺久美子、飯田宏樹、土肥修司
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡市、日本
  • Year and Date: 2010-06-03
• [Presentation] 気管平滑筋におけるDopamine D2受容体の発現とその機能的役割 (2010)
  • Author(s): 水田健太郎、Chang Yi、Xu Dingbang、杉山陽子、正木英二、Emala CW
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡市、日本
  • Year and Date: 2010-06-03
• [Presentation] Diabetes-Induced Tactile Allodynia Involves Activation of Adenylyl Cyclase in Rat Sensory Neurones. (2009)
  • Author(s): 杉山陽子、飯田宏樹、土肥修司
  • Organizer: アメリカ麻酔学会
  • Place of Presentation: ニューオリンズ、米国
  • Year and Date: 2009-10-17
• [Presentation] Diabetes-Induced Tactile Allodynia Involves Activation of Adenylyl Cyclase in Rat Sensory Neurons (2009)
  • Author(s): 杉山陽子、飯田宏樹、土肥修司
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: ニューオリンズ、アメリカ
  • Year and Date: 2009-10-17
• [Presentation] 気管平滑筋のGABAB受容体はIP3合成を促進する (2009)
  • Author(s): 水田健太郎、水田文子、杉山陽子、Emala CW
  • Organizer: 日本麻酔科学会第56回学術集会
  • Place of Presentation: 神戸市、日本
  • Year and Date: 2009-08-16