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Effects of GABAB receptors on Immune System in Airway Epithelium

Research Project

Project/Area Number 21791444
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionGifu University

Principal Investigator

SUGIYAMA Yoko  Gifu University, 医学系研究科, 助教 (70444255)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords気道 / 免疫 / シグナル伝達 / サイトカイン / ムチン / 麻酔薬 / GABA受容体 / IL-8 / シグナル伝逹
Research Abstract

Propofol enhanced TNF α induced-IL8 production via GABAA receptors in human airway epithelial cells. GABAB receptor agonists had no effect on IL-8 production. Midazolam inhibited TGF α induced-MUC5AC production in a GABAA receptor independent manner. These results suggest that GABAA receptors may become a new therapeutic target of airway inflammation.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2010 2009

All Presentation (5 results)

  • [Presentation] 気道上皮細胞のサイトカイン産生におけるプロポフォールの作用2010

    • Author(s)
      杉山陽子、田辺久美子、飯田宏樹、土肥修司
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡市、日本
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 気管平滑筋におけるDopamine D2受容体の発現とその機能的役割2010

    • Author(s)
      水田健太郎、Chang Yi、Xu Dingbang、杉山陽子、正木英二、Emala CW
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡市、日本
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Diabetes-Induced Tactile Allodynia Involves Activation of Adenylyl Cyclase in Rat Sensory Neurones.2009

    • Author(s)
      杉山陽子、飯田宏樹、土肥修司
    • Organizer
      アメリカ麻酔学会
    • Place of Presentation
      ニューオリンズ、米国
    • Year and Date
      2009-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Diabetes-Induced Tactile Allodynia Involves Activation of Adenylyl Cyclase in Rat Sensory Neurons2009

    • Author(s)
      杉山陽子、飯田宏樹、土肥修司
    • Organizer
      American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      ニューオリンズ、アメリカ
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 気管平滑筋のGABAB受容体はIP3合成を促進する2009

    • Author(s)
      水田健太郎、水田文子、杉山陽子、Emala CW
    • Organizer
      日本麻酔科学会第56回学術集会
    • Place of Presentation
      神戸市、日本
    • Year and Date
      2009-08-16
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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