Elucidation of anti-inflammatory effect of local-anesthetic
| Project/Area Number |
21791467
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka City University |
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Principal Investigator |
HASE Ichiro 大阪市立大学, 大学院・医学研究科, 講師 (60325628)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アミド型局所麻酔薬 / 脳 / 組織内濃度 / リドカイン / ブピバカイン / レボブピバカイン / 血中濃度 / 蛋白結合率 / 質量分析 |
|---|
| Research Abstract |
It isnecessary forelucidation of anti-inflammatory effect of local anesthetic to the quantification of the concentration of the local anesthetics in the blood and in the tissue. So we established the method of the he quantification of the concentration of the local anesthetics by microdialysis using the retrodialysis calibration method. No differences in the ratio of total brain concentration to total plasma concentration among the three anesthetics, butthe ratio of cerebral extracellular fluid concentration to plasma unbound fraction of bupivacaine was significantly higher than lidocaine and levobupivacaine.
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Report
(4 results)
Research Products
(38 results)
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[Presentation] 癌性疼痛患者の神経障害性疼痛に対するガバペンチンの有効性の検討2010
Author(s)
清水雅子, 長谷一郎, 池上里美, 鶴田理恵, 星学, 松井徳造, 中尾吉孝, 高橋陵太, 宮田妙子, 舟尾友晴, 浅田章
Organizer
第15回日本緩和医療学会学術大会3
Place of Presentation
東京
Related Report
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