Central nervous system effect of local anesthetics : Influences on electroencephalogram and electroencephalographic changes induced by co-administered opioids
| Project/Area Number |
21791468
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Osaka City University |
|---|
Principal Investigator |
TANAKA Katsuaki 大阪市立大学, 大学院・医学研究科, 講師 (60445038)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 局所麻酔薬 / 脳 / 脳波 / 麻薬性鎮痛薬 / フェンタニル / レミフェンタニル / 血中濃度 / Target Controlled Infusion / マイクロダイアライシス |
|---|
| Research Abstract |
Under general anesthesia, a guide cannula for microdialysis was placed into nucleus accumbens of a rat. And an electroencephalogram electrode was placed into opposite nucleus accumbens. Thereafter, serial measurement of topical electroencephalogram and quantification of local anesthetics were enabled in awake state. In human study, influences on bispectral index(BIS) induced by local anesthetics administered via epidural catheters and by co-administered opioid analgesics intravenously were investigated. Following one hour after continuous epidural infusion of local anesthetics, electroencephalographic changes of BIS were stabilized. This finding suggests that effect site concentration of local anesthetics and of opioid analgesics reached steady state.
|
Report
(4 results)
Research Products
(42 results)
