| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Compensatory hypertrophy (CH) in the donor's residual kidney may induce a higher GFR in the transplanted kidney. We evaluated the relationship between the gene polymorphisms of tissue growth factor such as IGF-1 or GH and the CH in the donor's residual kidney. In addition, we surveyed whether the CH in the donor's residual kidney affect the renal function of hemi-nephrectomized donor and the prognosis of donor.
In this study, we coudn't evaluate the relationship between the gene polymorphisms of tissue growth factor and clinical data including the incidence of compensatory hypertrophy of the donor kidney. In the immunohistochemical study, we couldn't evaluate them because almost all of 0 hour biopsy specimens showed negative staining. Almost all donors kept the renal function well. There was no relationship between the incidence of compensatory hypertrophy of the donor kidney and the donors who impaired the renal function or died.
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