The effect of subthalamic nucleus deep brain stimulation (STN-DBS) on the neuronal activity and the neurotransmitter in higher micturition centre
Project/Area Number |
21791489
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Urology
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Research Institution | Chiba University |
Principal Investigator |
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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Keywords | 泌尿器科学 / 大脳基底核 / パーキンソン病 / 線条体 / 視床下核 / 膀胱収縮間隔 / カテコラミン / local field potential / パーキンソン病モデルラット / ドパミン / 排尿反射 / スペクトラム解析 / 視床下核DBS / local field potential(LFP) |
Research Abstract |
We initially investigated the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on the micturition reflex, local field potential in the STN, and the levels of catecholamine in the striatum, respectively. STN-DBS significantly inhibit the micturition reflex and increase the power in the . frequency (around 20Hz) in STN. Dopamine metabolites (DOPAC and HVA) in the striatum were slightly increased by STN-DBS without statistically significance. In the next, we generated Parkinson's disease model rat (PD rat) by stereotaxically injecting 6-OHDA into the medial forebrain bundle in normal rat. STN-DBS significantly inhibited micturiton reflex in some PD rats and the power in the . frequency in STN. Striatal DOPAC was significantly decreased by STN-DBS. This study showed that the effect of STN-DBS was different between normal and PD model rat, which might be important in examining the physiological mechanisms of STN-DBS.
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Report
(4 results)
Research Products
(26 results)