Amelioration of Acute Tubular Necrosis in Ischemic Acute Renal Failure was Impaired in Mice Lucking Hypoxia Inducible Factor-1α Gene
| Project/Area Number |
21791506
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YAMAGUCHI Kunihisa The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (90464346)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | HIF-α / IRI / 再生 / HIF-1a / HIF-1α |
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| Research Abstract |
The mutant mice(HIF-1 kd) showed a prolonged elevation of blood urea nitrogen (BUN) levels up after ischemia-reperfusion, compared to the control mice. On the other hand, the cell proliferation that was evaluated by expression of Ki-67 increased in the control mice, in comparison with the mutant mice from early phase. Thus, tissue damage by ischemic injury was prolonged and recovery of renal function was delayin the mutant mice kidney. We are going to pursue further mechanism about this problem according to results of microarray analysis.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Adiponectin inhibits insulin-like growth factor-1-induced cell migration by the suppression of extracellular signal-regulated kinase 1/2 activation, but not Akt in vascular smooth muscle cells.2009
Author(s)
Motobayashi Y, Izawa-Ishizawa Y, Ishizawa K, Orino S, Yamaguchi K, Kawazoe K, Hamano S, Tsuchiya K, Tomita S, Tamaki T
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Journal Title
Hypertens Res 32・3
Pages: 188-193
NAID
Related Report
Peer Reviewed
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