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Therapy for advanced renal cancer via ER stress modulation

Research Project

Project/Area Number 21791533
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionOsaka Medical College

Principal Investigator

INAMOTO Teruo  大阪医科大学, 医学部, 助教 (20330087)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordssunitinib / IL-2 / 腎癌 / 生存 / 転移
Research Abstract

Modulation of growth factor signaling ; The epidermal growth factor receptor is expressed in a variety of human malignancies, including head and neck, breast, colorectal, lung, prostate, kidney, ovary, brain, pancreas, and bladder cancers. Epidermal growth factor receptor(EGFR) is a potential target for the treatment of urologic malignancies but a clinical response is expected in a small proportion. To come up with potential markers of response to EGFR tagetted therapy in cell lines, cell lines were investigated for anti-growth response to EGFR-therapy. E-cadherin was silenced by small interfering RNA in two sensitive cell lines, and the effect on the response to drugs was tested. Expression of intact ErbB4, E-cadherin, and b-catenin and loss of expression of platelet-derived growth factor receptor were associated with response to drug sensitivity. E-cadherin seems to play a central role in modulation of EGFR response.
Nuclear receptor signaling ; The peroxisome proliferator-activated receptor(PPAR) is a group of transcription factors that regulates cell growth, fatty acid regulation, and immune surveillance. Evidence is certainly accumulating for presence of PPAR in bladder cancer tissues. It is reported that PPAR agonist specifically increases natural killer T-lymphocytes specific markers. In addition to the close association between immune system and PPAR activation, PPAR agonists such as rosiglitazone to BCG regimens may have potent antitumor effects since bladder cancer cell lines demonstrates dose dependent inhibition of cancer cell growth in the presence of the PPAR agonist. Given these findings, along with previous findings, translational usage of molecular targets in clinical settings is awaited.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report

Research Products

(26 results)

All 2011 2010 2009

All Journal Article Presentation

  • [Journal Article] Sorafenib increases endoplasmic reticulum (ER) stress in concert with vorinostat2011

    • Author(s)
      Inamoto T, Azuma H
    • Journal Title

      Cancer Biol Ther

      Volume: 12 Pages: 12-12

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Receptor heterodimerization : a new mechanism for platelet-derived growth factor induced resistance to anti-epidermal growth factor receptor the rapy for bladder cancer2011

    • Author(s)
      Black PC, Brown GA, Dinney CP, Kassouf W, Inamoto T, Arora A, Gallagher D, Munsell MF, Bar-Eli M, McConkey DJ, Adam L
    • Journal Title

      J Urol

      Volume: 185 Pages: 693-700

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic mislocalization of the orphan nuclear receptor Nurr1 is a prognostic factor in bladder cancer2010

    • Author(s)
      Inamoto T, Czerniak BA, Dinney CP, Kamat AM
    • Journal Title

      Cancer

      Volume: 15, 116(2) Pages: 340-346

    • DOI

      10.1002/cncr.24737

    • Related Report
      2011 Final Research Report
  • [Journal Article] Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers.2010

    • Author(s)
      Tharakan ST, Inamoto T, Sung B, Aggarwal BB, Kamat AM.
    • Journal Title

      Biochem Pharmacol.

      Volume: 79 Pages: 218-28

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic mislocalization of the orphan nuclear receptor Nurrl is a prognostic factor in bladder cancer.2010

    • Author(s)
      Inamoto T, Czerniak BA,Dinney CP, Kamat AM.
    • Journal Title

      Cancer.

      Volume: 116 Pages: 340-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Evaluation of Minimum-incision Endoscopic Radical Prostatectomy in Initial 50 Patients.2010

    • Author(s)
      Hamada S, Azuma H, Inamoto T, Katsuoka Y.
    • Journal Title

      Asian J Surg.

      Volume: 33 Pages: 181-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers2009

    • Author(s)
      Tharakan ST, Inamoto T, Sung B, Aggarwal BB, Kamat AM
    • Journal Title

      Biochem Pharmacol

    • DOI

      10.1016/j.bcp.2009.08.007

    • Related Report
      2011 Final Research Report
  • [Journal Article] Conversion of prostate cancer from hormone independency to dependency due to AMACR inhibition : involvement of increased AR expression and decreased IGF1 expression2009

    • Author(s)
      Takahara K, Azuma H, Sakamoto T, Kiyama S, Inamoto T, Ibuki N, Nishida T, Nomi H, Ubai T, Segawa N, Katsuoka Y
    • Journal Title

      Anticancer Res

      Volume: 29(7) Pages: 2497-505

    • URL

      http://ar.iiarjournals.org/content/29/7/2497.long

    • Related Report
      2011 Final Research Report
  • [Journal Article] Gemicitabine resistence and mesenchymal phenotype2009

    • Author(s)
      Inamoto T, Azuma H, Katsuoka Y
    • Journal Title

      Ann Surg Oncol

      Volume: 16(5) Pages: 1435-1436

    • DOI

      10.1245/s10434-008-0309-0

    • Related Report
      2011 Final Research Report
  • [Journal Article] Friend or foe? Role of peroxisome proliferator-activated receptor-gamma in human bladder cancer2009

    • Author(s)
      Inamoto T, Shah JB, Kamat AM
    • Journal Title

      Urol Oncol

      Volume: 27(6) Pages: 585-691

    • Related Report
      2011 Final Research Report
  • [Journal Article] Friend or foe? Role of peroxisome proliferator-activated receptor-gamma in human bladder cancer2009

    • Author(s)
      Inamoto T, Shah JB, Kamat AM.
    • Journal Title

      Urol Oncol. 6

      Pages: 585-91

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gemicitabine resistence and mesenchymal phenotype2009

    • Author(s)
      Inamoto T, Azuma H, Katsuoka Y.
    • Journal Title

      Ann Surg Oncol. 5

      Pages: 1435-6

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Extracorporeal shock wave lithotripsy as a first-line therapy for ureteral calculi with impaired renal function due to hydronephrosis2009

    • Author(s)
      Inamoto T, Azuma H, Katsuoka Y.
    • Journal Title

      Surg Endosc. 7

      Pages: 1674-1674

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Conversion of prostate cancer from hormone independency to dependency due to AMACR inhibition : involvement of increased AR expression and decreased IGF1 expression2009

    • Author(s)
      Takahara K, Azuma H, Sakamoto T, Kiyama S, Inamoto T, Ibuki N, Nishida T, Nomi H, Ubai T, Segawa N, Katsuoka Y.
    • Journal Title

      Anticancer Res. 7

      Pages: 2497-505

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers2009

    • Author(s)
      Tharakan ST, Inamoto T, Sung B, Aggarwal BB, Kamat AM.
    • Journal Title

      Biochem Pharmacol. 2

      Pages: 218-28

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic mislocalization of the orphan nuclear receptor Nurr1 is a prognostic factor in bladder cancer2009

    • Author(s)
      Inamoto T, Czerniak BA, Dinney CP, Kamat AM.
    • Journal Title

      Cancer 2

      Pages: 340-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 第99回日泌総会フロンティア企画;癌細胞自体の転写調節を撹乱させる抗癌治療「神経成長因子IB刺激治療」の試み2011

    • Author(s)
      稲元輝生
    • Organizer
      第99日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-04-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新旧のMotzer分類を用いた腎癌の予後予測2010

    • Author(s)
      稲元輝生、小村和正、東治人、勝岡洋治
    • Organizer
      第60回 日本泌尿器科学会中部総会
    • Place of Presentation
      名古屋マリオットアソシアホテル(名古屋)
    • Year and Date
      2010-11-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 限局性前立腺癌に対するHIFU治療後の生化学的再発に対するホルモン療法の影響2010

    • Author(s)
      稲元輝生, 藤末裕, 小村和正, 増田裕, 和辻利一, 東治人, 勝岡洋治
    • Organizer
      第60回 日本泌尿器科学会中部総会
    • Place of Presentation
      名古屋マリオットアソシアホテル(名古屋)
    • Year and Date
      2010-11-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高リスク群の限局性前立腺癌に対する腹腔鏡手術前ホルモン療法の意義2010

    • Author(s)
      稲元輝生, 伊夫貴直和, 小山耕平, 水谷陽一, 右梅貴信, 東治人, 勝岡洋治
    • Organizer
      第24回日本Endourology・ESWL学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cytoplasmic mislocalization of the orphan nuclear receptor is a prognostic factor in bladder cancer2009

    • Author(s)
      Inamoto T, Azuma H, Kotake Y, Ubai T, Watanabe M, Katsuoka Y
    • Organizer
      Societe Internationale d' Urologie
    • Place of Presentation
      シャンハイ(中国)
    • Year and Date
      2009-11-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Gamma-aminobutyric acid modulates invasive property in renal cancer2009

    • Author(s)
      Inamoto T, Dinney CP, Czerniak B, Kamat AM
    • Organizer
      Societe Internationale d' Urologie
    • Place of Presentation
      Shanghai, Chinaシャンハイ(中国)
    • Year and Date
      2009-11-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Transforming Growth Factor-beta Regulates Neuroendocrine Like Transdifferentiation of Human Prostate2009

    • Author(s)
      Inamoto T, Ibuki N, Koyama K, Komura K, Fujisue Y, Kotake Y, Ubai T, Azuma H, and Katsuoka Y
    • Organizer
      5th Congress of Asia Pacific Society for the Study of Aging Ma
    • Place of Presentation
      Osaka, Japan(大阪)
    • Year and Date
      2009-10-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Inhibition of Erbb4/HER4 cleavage potentiates gefitinib sensitivity in urothelial carcinoma2009

    • Author(s)
      Black P, Inamoto T, Fisher M, Hegarty P, Arora A, Bar-Eli M, Dinney C, and McConkey D
    • Organizer
      Can Urol Assoc
    • Place of Presentation
      サンディエゴ(USA)
    • Related Report
      2011 Final Research Report
  • [Presentation] Receptor heterodimerization : a new mechanism for platelet-derived growth factor-induced resistance to anti-epidermal growth factor receptor therapy in bladder cancer2009

    • Author(s)
      Black P, Brown G, McConkey D, Kassouf W, Inamoto T, Arora A, Gallagher D, Munsell M, Bar-Eli M, Dinney C, and Adam L
    • Organizer
      Can Urol Assoc
    • Place of Presentation
      サンディエゴ(USA)
    • Related Report
      2011 Final Research Report
  • [Presentation] Donor-specific tolerance induced by treatment with Superagonistic CD28 antibody in rat renal allografts2009

    • Author(s)
      Azuma, H. Nomi, H., Ubai, T., Inamoto, T., Ibuki, N., Koyama, K., Isaka, Y., Takahara, S., Katsuoka, Y.
    • Organizer
      The American Urological Association(AUA)'s Annual Meeting
    • Place of Presentation
      シカゴ(USA)
    • Related Report
      2011 Final Research Report

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Published: 2009-03-31   Modified: 2019-06-06  

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