Expression of miRNA in human epithelial ovarian cancer
| Project/Area Number |
21791537
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
|---|
Principal Investigator |
AKAHIRA Junichi 東北大学, 大学院・医学系研究科, 非常勤講師 (90359505)
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|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 婦人科腫瘍学 / 卵巣癌 / マイクロRNA / 子宮体癌 |
|---|
| Research Abstract |
miR-34b was found to have promoter hypermethylation, which when reversed, restored miR-34b expression in the endometrial serous cancer (ESC)cell lines treated with 5-aza-2' deoxycytidine. miR-34b transfection inhibited ESC cell growth, migration and most notably invasion. These effects were mediated by miR-34b target gene, the mesenchymal epithelial transition factor (MET). The expression of MET was reduced following the restoration of miR-34b in ESC cell lines. In summary, our data suggest that miR-34b plays a role in the molecular pathogenesis of endometrial cancer.
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Report
(4 results)
Research Products
(20 results)
