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Global analysis of the roles of neurotrophic factors in female reproductions and their clinical applications

Research Project

Project/Area Number 21791539
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionAkita University

Principal Investigator

KAWAMURA Kazuhiro  秋田大学, 医学部, 講師 (10344756)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords神経栄養因子 / 卵胞発育 / 胚発育 / 着床 / 絨毛発育
Research Abstract

Recent studies revealed that, in addition to sex hormones, networks of diverse growth factors and cytokines have been shown to regulate reproductive functions. In this project, we focused on the roles of neurotrophic factors as novel regulators of female reproductive functions in early follicle growth, preimplantation embryo growth and implantation, and subsequent trophoblasts and placental growth. We demonstrated that BDNF/TrkB signaling had important roles in preimplantation embryo growth and implantation, and subsequent trophoblasts and placental growth.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (45 results)

All 2012 2011 2010 2009

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (26 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Intraovarian thrombin and activated protein C signaling system regulates steroidogenesis during the periovulatoryperiod2012

    • Author(s)
      Cheng Y, Kawamura K, Deguchi M, Takae S, Mulders SM, Hsueh AJ
    • Journal Title

      Mol Endocrinol

      Volume: 26 Issue: 2 Pages: 331-340

    • DOI

      10.1210/me.2011-1187

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] T. Brain-derived neurotrophic factor/tyrosine kinase B signaling regulates human trophoblast growth in an in vivo animal model of ectopic pregnancy2011

    • Author(s)
      Kawamura K, Kawamura N, Kumazawa Y, Kumagai J, Fujimoto T, Tanaka T
    • Journal Title

      Endocrinology

      Volume: 152 Issue: 3 Pages: 1090-1100

    • DOI

      10.1210/en.2010-1124

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pre-ovulatory LH/hCG surge decreases C-type natriuretic peptide secretion by ovarian granulosa cells to promote meiotic resumption of pre-ovulatory oocytes2011

    • Author(s)
      Kawamura K, Cheng Y, Kawamura N, Takae S, Okada A, Kawagoe Y, Mulders S, Terada Y, Hsueh AJ
    • Journal Title

      Hum Reprod

      Volume: 26 Issue: 11 Pages: 331-340

    • DOI

      10.1093/humrep/der282

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain-derived neurotrophic factor/tyrosine kinase B signaling regulates human trophoblast growth in an in vivo animal model of ectopic pregnancy.2011

    • Author(s)
      Kawamura K,, Kawamura N, Kumazawa Y, Kumagai J, Fujimoto T, Tanaka T
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 1090-1100

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] nhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth2010

    • Author(s)
      Kawamura N, Kawamura K, Manabe M, Tanaka T
    • Journal Title

      Endocrinology

      Volume: 151 Issue: 7 Pages: 3006-3014

    • DOI

      10.1210/en.2009-1378

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth.2010

    • Author(s)
      Kwamura N, Kawamura K, Manabe M, Tanaka T
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 3006-3014

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increasing levels of amphiregulin in follicular fruids are associated with human oocyte maturation2010

    • Author(s)
      Sasaki M, et al.
    • Journal Title

      Akita J Med (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of possible criteria for elective single embryo transfer2010

    • Author(s)
      Sasaki M, et al.
    • Journal Title

      Akita J Med (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paracrine regulation of the resumption of oocyte meiosis by endothelin-12009

    • Author(s)
      Kawamura K, Ye Y, Liang CG, Kawamura N, Gelpke MS, Rauch R, Tanaka T, Hsueh AJ
    • Journal Title

      Dev Biol

      Volume: 327 Issue: 1 Pages: 62-70

    • DOI

      10.1016/j.ydbio.2008.11.033

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes2009

    • Author(s)
      Ye Y, Kawamura K, Sasaki M, Kawamura N, Groenen P, Gelpke MD, Rauch R, Hsueh AJ, Tanaka T
    • Journal Title

      Reprod Biol Endocrinol

      Volume: 7 Issue: 1 Pages: 26-26

    • DOI

      10.1186/1477-7827-7-26

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leptin promotes oocyte development into preimplantation embryos and involvement of Ob-Ra/MEK signaling in the leptin mediated oocyte nuclear maturation2009

    • Author(s)
      Ye Y, Kawamura K, Sasaki M, Kawamura N, Groenen P, Sollewijn Gelpke MD, Kumagai J, Fukuda J, Tanaka T
    • Journal Title

      Reprod Biomed Online

      Volume: 19 Pages: 181-190

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/19712552

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain-derived neurotrophic factor promotes implantation and subsequent placental development by stimulating trophoblast cell growth and survival2009

    • Author(s)
      Kawamura K, Kawamura N, Sato W, Fukuda J, Kumagai J, Tanaka T
    • Journal Title

      Endocrinology

      Volume: 150 Issue: 8 Pages: 3774-3782

    • DOI

      10.1210/en.2009-0213

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paracrine regulation of the resumption of oocyte meiosis by endothelin-12009

    • Author(s)
      Kawamura K, et al.
    • Journal Title

      Dev Biol 327

      Pages: 62-70

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes2009

    • Author(s)
      Ye Y, et al.
    • Journal Title

      Reprod Biol Endocrinol 7

      Pages: 26-26

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leptin promotes oocyte development into preimplantation embryos and involvement of Ob-Ra/MEK signaling in the leptin mediated oocyte nuclear maturation2009

    • Author(s)
      Ye Y, et al.
    • Journal Title

      Reprod Biomed Online 19

      Pages: 181-190

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain-derived neurotrophic factor promotes implantation and subsequent placental development by stimulating trophoblast cell growth and survival2009

    • Author(s)
      Kawamura K, et al.
    • Journal Title

      Endocrinology 150

      Pages: 3774-3782

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] WAKING UP DORMANT OVARIAN FOLLICLES2011

    • Author(s)
      Kazuhiro Kawamura
    • Organizer
      The XXII Asian and Oceanic Congress of Obstetrics and Gynecology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] BDNF/TrkBシグナルによるヒトtrophoblastの発育制御2011

    • Author(s)
      河村和弘, 白澤弘光, 熊澤由紀代, 熊谷仁, 寺田幸弘
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 卵成熟を誘導する新規体細胞由来因子の同定2011

    • Author(s)
      河村和弘
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      盛岡
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] BDNF/TrkBシグナルを標的とした異所生妊娠に対する新規薬物療法2011

    • Author(s)
      河村和弘, 河村七美, 熊澤由紀代, 熊谷仁, 寺田幸弘
    • Organizer
      第19回日本胎盤学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 生殖におけるBDNF/TrkBシグナルの役割2011

    • Author(s)
      河村和弘
    • Organizer
      第56回日本生殖医学会学術講演会・総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 休眠原始卵胞の人為的活性化2011

    • Author(s)
      河村和弘
    • Organizer
      第52回日本哺乳動物卵子学会総会・学術講演会
    • Place of Presentation
      栃木
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮内膜症による卵子の質の悪化とその対策2011

    • Author(s)
      河村和弘
    • Organizer
      第52回日本哺乳動物卵子学会総会・学術講演会
    • Place of Presentation
      栃木
    • Related Report
      2011 Annual Research Report
  • [Presentation] 減数分裂再開過程における卵成熟抑制因子:C-type natriuretic peptideの役割2011

    • Author(s)
      河村和弘
    • Organizer
      第29回日本受精着床学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 休眠原始卵胞の活性化によるヒトおよびマウス成熟卵の算出2010

    • Author(s)
      河村和弘
    • Organizer
      第55回日本生殖医学会総会・学術講演会
    • Place of Presentation
      徳島県郷土文化会館(徳島)
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Roles of BDNF/TrkB signaling in reproduction2010

    • Author(s)
      Kazuhiro Kawamura
    • Organizer
      FertiLink2010
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-10-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Roles of BDNF/TrkB signaling in reproduction2010

    • Author(s)
      Kawamura K
    • Organizer
      FertiLink2010
    • Place of Presentation
      ウェスティン都ホテル京都(京都)
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Brain-derived neurotrophic factor (BDNF)による着床と胎盤発育の促進とその分子機構の解析2010

    • Author(s)
      河村和弘
    • Organizer
      第18回日本胎盤学会学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2010-09-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Brain-derived neurotrophic factor (BDNF)による着床と胎盤発育の促進とその分子機構の解析2010

    • Author(s)
      河村和弘
    • Organizer
      第18回日本胎盤学会学術集会
    • Place of Presentation
      ホテル日航熊本(熊本)
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] パラクライン/オートクライン因子による胚発育調節2010

    • Author(s)
      河村和弘
    • Organizer
      第28回日本受精着床学会総会・学術講演会
    • Place of Presentation
      横浜
    • Year and Date
      2010-07-28
    • Related Report
      2011 Final Research Report
  • [Presentation] パラクライン/オートクライン因子による胚発育調節2010

    • Author(s)
      河村和弘
    • Organizer
      第28回日本受精着床学会総会・学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2010-07-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 卵子成熟機構の障害とIVM2010

    • Author(s)
      河村和弘
    • Organizer
      第51回日本哺乳動物卵子学会・学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト休止原始卵胞の賦活化による成熟卵の算出2010

    • Author(s)
      河村和弘、熊澤由紀代、熊谷仁、田中俊誠
    • Organizer
      第62回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regulation of oocyte nuclear and cytoplasmic maturation by ovarian paracrine factors2009

    • Author(s)
      河村和弘, et al.
    • Organizer
      The International Ovarian Conference 2009
    • Place of Presentation
      東京
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] brain-derived neurotrophic factor(BDNF)による着床と胎盤発育の制御とその分子機構2009

    • Author(s)
      河村和弘, 等
    • Organizer
      第14回日本生殖内分泌学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] パラクライン・オートクライン因子による胚発育、卵成熟調節2009

    • Author(s)
      河村和弘
    • Organizer
      第61回日本産科婦人科学会学総会・学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 中枢神経関連生理活性物質の卵成熟・胚発育・着床への影響2009

    • Author(s)
      河村和弘
    • Organizer
      第61回日本産科婦人科学会学総会・学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規母体由来卵成熟因子の固定:endothelin-1/EDNRA signaling system2009

    • Author(s)
      河村和弘, 等
    • Organizer
      第27回日本受精着床学会総会・学術講演会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] brain-derived neurotrophic factor(BDNF)による絨毛・胎盤発育の制御とその分子機構2009

    • Author(s)
      河村和弘, 等
    • Organizer
      第27回周産期医療研究会
    • Place of Presentation
      秋田
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規母体由来卵成熟因子の同定:endothelin-1/EDNRA signaling system2009

    • Author(s)
      河村和弘, 等
    • Organizer
      第50回日本哺乳動物卵子学会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規母体由来卵成熟因子の同定:endothelia-1/EDNRA signaling system2009

    • Author(s)
      熊谷仁, 等
    • Organizer
      第54回日本生殖医学会総会・学術講演会
    • Place of Presentation
      石川
    • Related Report
      2009 Annual Research Report
  • [Presentation] 着床と胎盤発育を制御する新規因子の同定とその分子機構の解明:brain-derived neurotrophic factor(BDNF)2009

    • Author(s)
      河村和弘, 等
    • Organizer
      第54回日本生殖医学会総会・学術講演会
    • Place of Presentation
      石川
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 子宮外妊娠の治療剤2011

    • Inventor(s)
      河村和弘
    • Industrial Property Rights Holder
      河村和弘
    • Filing Date
      2011-12-28
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 絨毛癌の治療剤2010

    • Inventor(s)
      河村和弘
    • Industrial Property Rights Holder
      河村和弘
    • Industrial Property Number
      2010-185384
    • Filing Date
      2010-08-20
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 子宮外妊娠の治療剤2010

    • Inventor(s)
      河村和弘
    • Industrial Property Rights Holder
      河村和弘
    • Industrial Property Number
      2010-294391
    • Filing Date
      2010-12-29
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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